A poroelastic model coupled to a fluid network with applications in lung modelling.
We develop a lung ventilation model based on a continuum poroelastic representation of lung parenchyma that is strongly coupled to a pipe network representation of the airway tree. The continuous system of equations is discretized using a low-order stabilised finite element method. The framework is...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
John Wiley and Sons, Ltd
2016
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| _version_ | 1797073572698521600 |
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| author | Berger, L Bordas, R Burrowes, K Grau, V Tavener, S Kay, D |
| author_facet | Berger, L Bordas, R Burrowes, K Grau, V Tavener, S Kay, D |
| author_sort | Berger, L |
| collection | OXFORD |
| description | We develop a lung ventilation model based on a continuum poroelastic representation of lung parenchyma that is strongly coupled to a pipe network representation of the airway tree. The continuous system of equations is discretized using a low-order stabilised finite element method. The framework is applied to a realistic lung anatomical model derived from computed tomography data and an artificially generated airway tree to model the conducting airway region. Numerical simulations produce physiologically realistic solutions and demonstrate the effect of airway constriction and reduced tissue elasticity on ventilation, tissue stress and alveolar pressure distribution. The key advantage of the model is the ability to provide insight into the mutual dependence between ventilation and deformation. This is essential when studying lung diseases, such as chronic obstructive pulmonary disease and pulmonary fibrosis. Thus the model can be used to form a better understanding of integrated lung mechanics in both the healthy and diseased states. Copyright © 2015 John Wiley and Sons, Ltd. |
| first_indexed | 2024-03-06T23:24:06Z |
| format | Journal article |
| id | oxford-uuid:69c76e78-3c23-4e87-a9c0-4c581f391160 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:24:06Z |
| publishDate | 2016 |
| publisher | John Wiley and Sons, Ltd |
| record_format | dspace |
| spelling | oxford-uuid:69c76e78-3c23-4e87-a9c0-4c581f3911602022-03-26T18:53:12ZA poroelastic model coupled to a fluid network with applications in lung modelling.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:69c76e78-3c23-4e87-a9c0-4c581f391160EnglishSymplectic Elements at OxfordJohn Wiley and Sons, Ltd2016Berger, LBordas, RBurrowes, KGrau, VTavener, SKay, DWe develop a lung ventilation model based on a continuum poroelastic representation of lung parenchyma that is strongly coupled to a pipe network representation of the airway tree. The continuous system of equations is discretized using a low-order stabilised finite element method. The framework is applied to a realistic lung anatomical model derived from computed tomography data and an artificially generated airway tree to model the conducting airway region. Numerical simulations produce physiologically realistic solutions and demonstrate the effect of airway constriction and reduced tissue elasticity on ventilation, tissue stress and alveolar pressure distribution. The key advantage of the model is the ability to provide insight into the mutual dependence between ventilation and deformation. This is essential when studying lung diseases, such as chronic obstructive pulmonary disease and pulmonary fibrosis. Thus the model can be used to form a better understanding of integrated lung mechanics in both the healthy and diseased states. Copyright © 2015 John Wiley and Sons, Ltd. |
| spellingShingle | Berger, L Bordas, R Burrowes, K Grau, V Tavener, S Kay, D A poroelastic model coupled to a fluid network with applications in lung modelling. |
| title | A poroelastic model coupled to a fluid network with applications in lung modelling. |
| title_full | A poroelastic model coupled to a fluid network with applications in lung modelling. |
| title_fullStr | A poroelastic model coupled to a fluid network with applications in lung modelling. |
| title_full_unstemmed | A poroelastic model coupled to a fluid network with applications in lung modelling. |
| title_short | A poroelastic model coupled to a fluid network with applications in lung modelling. |
| title_sort | poroelastic model coupled to a fluid network with applications in lung modelling |
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