3'-Azido-3'-deoxythymidine drug resistance mutations in HIV-1 reverse transcriptase can induce long range conformational changes.

HIV reverse transcriptase (RT) is one of the main targets for the action of anti-AIDS drugs. Many of these drugs [e.g., 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxyinosine (ddI)] are analogues of the nucleoside substrates used by the HIV RT. One of the main problems in anti...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों:	Ren, J, Esnouf, R, Hopkins, A, Jones, E, Kirby, I, Keeling, J, Ross, C, Larder, B, Stuart, D, Stammers, D
स्वरूप:	Journal article
भाषा:	English
प्रकाशित:	1998

3'-Azido-3'-deoxythymidine drug resistance mutations in HIV-1 reverse transcriptase can induce long range conformational changes.

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