3'-Azido-3'-deoxythymidine drug resistance mutations in HIV-1 reverse transcriptase can induce long range conformational changes.

3'-Azido-3'-deoxythymidine drug resistance mutations in HIV-1 reverse transcriptase can induce long range conformational changes.

HIV reverse transcriptase (RT) is one of the main targets for the action of anti-AIDS drugs. Many of these drugs [e.g., 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxyinosine (ddI)] are analogues of the nucleoside substrates used by the HIV RT. One of the main problems in anti...

Mô tả đầy đủ

Chi tiết về thư mục
Những tác giả chính: Ren, J, Esnouf, R, Hopkins, A, Jones, E, Kirby, I, Keeling, J, Ross, C, Larder, B, Stuart, D, Stammers, D
Định dạng: Journal article
Ngôn ngữ:English
Được phát hành: 1998

Những quyển sách tương tự