Tissue plasminogen activator does not increase neuronal damage in rat models of global and focal ischemia.

Tissue plasminogen activator does not increase neuronal damage in rat models of global and focal ischemia.

BACKGROUND: Intravenous tissue plasminogen activator (tPA) is the only approved treatment for acute ischemic stroke. Recent results from both in vitro and in vivo animal model experiments suggest the possibility that tPA is neurotoxic. METHODS: The authors evaluated the putative neurotoxicity of tPA...

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Autori principali:	Klein, G, Li, H, Sun, P, Buchan, A
Natura:	Journal article
Lingua:	English
Pubblicazione:	1999

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