Vitamin D receptor polymorphisms and susceptibility to tuberculosis in West Africa: a case-control and family study.
Vitamin D receptor (VDR) gene polymorphisms have been implicated in susceptibility to tuberculosis (TB), but reports have been inconsistent. We genotyped the VDR single-nucleotide polymorphisms (SNPs) FokI, BsmI, ApaI, and TaqI in 1139 case patients and control subjects and 382 families from The Gam...
| Main Authors: | , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2004
|
| _version_ | 1797073612090376192 |
|---|---|
| author | Bornman, L Campbell, S Fielding, K Bah, B Sillah, J Gustafson, P Manneh, K Lisse, I Allen, A Sirugo, G Sylla, A Aaby, P McAdam, K Bah-Sow, O Bennett, S Lienhardt, C Hill, A |
| author_facet | Bornman, L Campbell, S Fielding, K Bah, B Sillah, J Gustafson, P Manneh, K Lisse, I Allen, A Sirugo, G Sylla, A Aaby, P McAdam, K Bah-Sow, O Bennett, S Lienhardt, C Hill, A |
| author_sort | Bornman, L |
| collection | OXFORD |
| description | Vitamin D receptor (VDR) gene polymorphisms have been implicated in susceptibility to tuberculosis (TB), but reports have been inconsistent. We genotyped the VDR single-nucleotide polymorphisms (SNPs) FokI, BsmI, ApaI, and TaqI in 1139 case patients and control subjects and 382 families from The Gambia, Guinea, and Guinea-Bissau. The transmission-disequilibrium test on family data showed a significant global association of TB with SNP combinations FokI-BsmI-ApaI-TaqI and FokI-ApaI that were driven by the increased transmission to affected offspring of the FokI F and ApaI A alleles in combination. The ApaI A allele was also transmitted to affected offspring significantly more often than expected. Case-control analysis showed no statistically significant association between TB and VDR variants. BsmI, ApaI, and TaqI showed strong linkage disequilibrium. The significance of the family-based associations found between TB and FokI-BsmI-ApaI-TaqI and the FA haplotype supports a role for VDR haplotypes, rather than individual genotypes, in susceptibility to TB. |
| first_indexed | 2024-03-06T23:24:31Z |
| format | Journal article |
| id | oxford-uuid:69e7fd2f-2642-492b-8b35-22dce7f61f18 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:24:31Z |
| publishDate | 2004 |
| record_format | dspace |
| spelling | oxford-uuid:69e7fd2f-2642-492b-8b35-22dce7f61f182022-03-26T18:54:05ZVitamin D receptor polymorphisms and susceptibility to tuberculosis in West Africa: a case-control and family study.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:69e7fd2f-2642-492b-8b35-22dce7f61f18EnglishSymplectic Elements at Oxford2004Bornman, LCampbell, SFielding, KBah, BSillah, JGustafson, PManneh, KLisse, IAllen, ASirugo, GSylla, AAaby, PMcAdam, KBah-Sow, OBennett, SLienhardt, CHill, AVitamin D receptor (VDR) gene polymorphisms have been implicated in susceptibility to tuberculosis (TB), but reports have been inconsistent. We genotyped the VDR single-nucleotide polymorphisms (SNPs) FokI, BsmI, ApaI, and TaqI in 1139 case patients and control subjects and 382 families from The Gambia, Guinea, and Guinea-Bissau. The transmission-disequilibrium test on family data showed a significant global association of TB with SNP combinations FokI-BsmI-ApaI-TaqI and FokI-ApaI that were driven by the increased transmission to affected offspring of the FokI F and ApaI A alleles in combination. The ApaI A allele was also transmitted to affected offspring significantly more often than expected. Case-control analysis showed no statistically significant association between TB and VDR variants. BsmI, ApaI, and TaqI showed strong linkage disequilibrium. The significance of the family-based associations found between TB and FokI-BsmI-ApaI-TaqI and the FA haplotype supports a role for VDR haplotypes, rather than individual genotypes, in susceptibility to TB. |
| spellingShingle | Bornman, L Campbell, S Fielding, K Bah, B Sillah, J Gustafson, P Manneh, K Lisse, I Allen, A Sirugo, G Sylla, A Aaby, P McAdam, K Bah-Sow, O Bennett, S Lienhardt, C Hill, A Vitamin D receptor polymorphisms and susceptibility to tuberculosis in West Africa: a case-control and family study. |
| title | Vitamin D receptor polymorphisms and susceptibility to tuberculosis in West Africa: a case-control and family study. |
| title_full | Vitamin D receptor polymorphisms and susceptibility to tuberculosis in West Africa: a case-control and family study. |
| title_fullStr | Vitamin D receptor polymorphisms and susceptibility to tuberculosis in West Africa: a case-control and family study. |
| title_full_unstemmed | Vitamin D receptor polymorphisms and susceptibility to tuberculosis in West Africa: a case-control and family study. |
| title_short | Vitamin D receptor polymorphisms and susceptibility to tuberculosis in West Africa: a case-control and family study. |
| title_sort | vitamin d receptor polymorphisms and susceptibility to tuberculosis in west africa a case control and family study |
| work_keys_str_mv | AT bornmanl vitamindreceptorpolymorphismsandsusceptibilitytotuberculosisinwestafricaacasecontrolandfamilystudy AT campbells vitamindreceptorpolymorphismsandsusceptibilitytotuberculosisinwestafricaacasecontrolandfamilystudy AT fieldingk vitamindreceptorpolymorphismsandsusceptibilitytotuberculosisinwestafricaacasecontrolandfamilystudy AT bahb vitamindreceptorpolymorphismsandsusceptibilitytotuberculosisinwestafricaacasecontrolandfamilystudy AT sillahj vitamindreceptorpolymorphismsandsusceptibilitytotuberculosisinwestafricaacasecontrolandfamilystudy AT gustafsonp vitamindreceptorpolymorphismsandsusceptibilitytotuberculosisinwestafricaacasecontrolandfamilystudy AT mannehk vitamindreceptorpolymorphismsandsusceptibilitytotuberculosisinwestafricaacasecontrolandfamilystudy AT lissei vitamindreceptorpolymorphismsandsusceptibilitytotuberculosisinwestafricaacasecontrolandfamilystudy AT allena vitamindreceptorpolymorphismsandsusceptibilitytotuberculosisinwestafricaacasecontrolandfamilystudy AT sirugog vitamindreceptorpolymorphismsandsusceptibilitytotuberculosisinwestafricaacasecontrolandfamilystudy AT syllaa vitamindreceptorpolymorphismsandsusceptibilitytotuberculosisinwestafricaacasecontrolandfamilystudy AT aabyp vitamindreceptorpolymorphismsandsusceptibilitytotuberculosisinwestafricaacasecontrolandfamilystudy AT mcadamk vitamindreceptorpolymorphismsandsusceptibilitytotuberculosisinwestafricaacasecontrolandfamilystudy AT bahsowo vitamindreceptorpolymorphismsandsusceptibilitytotuberculosisinwestafricaacasecontrolandfamilystudy AT bennetts vitamindreceptorpolymorphismsandsusceptibilitytotuberculosisinwestafricaacasecontrolandfamilystudy AT lienhardtc vitamindreceptorpolymorphismsandsusceptibilitytotuberculosisinwestafricaacasecontrolandfamilystudy AT hilla vitamindreceptorpolymorphismsandsusceptibilitytotuberculosisinwestafricaacasecontrolandfamilystudy |