Crystal structure of the GluR2 amino-terminal domain provides insights into the architecture and assembly of ionotropic glutamate receptors.

Ionotropic glutamate receptors are functionally diverse but have a common architecture, including the 400-residue amino-terminal domain (ATD). We report a 1.8-A resolution crystal structure of human GluR2-ATD. This dimeric structure provides a mechanism for how the ATDs can drive receptor assembly a...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron: Clayton, A, Siebold, C, Gilbert, R, Sutton, G, Harlos, K, McIlhinney, R, Jones, E, Aricescu, A
Fformat: Journal article
Iaith:English
Cyhoeddwyd: 2009