The pancreatic β cell: Recent insights from human genetics

The pancreatic β cell: Recent insights from human genetics

Show other versions (1)

Diabetes mellitus is a metabolic disease characterised by relative or absolute pancreatic β cell dysfunction. Genetic variants implicated in disease risk can be identified by studying affected individuals. To understand the mechanisms driving genetic associations, variants must be translated through...

書目詳細資料
Main Authors:	Thomsen, S, Gloyn, A
格式:	Journal article
語言:	English
出版:	Cell Press 2014

相似書籍

The pancreatic β cell: recent insights from human genetics.
由: Thomsen, S, et al.
出版: (2014)

Human genetics as a model for target validation: finding new therapies for diabetes
由: Thomsen, S, et al.
出版: (2017)

Monogenic disorders of the pancreatic β-cell: Personalizing treatment for rare forms of diabetes and hypoglycemia
由: van de Bunt, M, et al.
出版: (2007)

SSTR2 is the functionally dominant somatostatin receptor in human pancreatic β- and α-cells.
由: Kailey, B, et al.
出版: (2012)

Monogenic β-cell dysfunction in children: Clinical phenotypes, genetic etiology and mutational pathways
由: Waterfield, T, et al.
出版: (2008)

Insights into pancreatic β cell energy metabolism using rodent β cell models
由: Morten, K, et al.
出版: (2017)

Heterogeneity of human pancreatic β-cells
由: Giselle Dominguez-Gutierrez, et al.
出版: (2019-09-01)

Recent insights about autophagy in pancreatitis
由: Xiaowen Ma, et al.
出版: (2024-05-01)

Recent insights into the biology of pancreatic cancer
由: Wantong Yao, et al.
出版: (2020-03-01)

Recent insights into the cellular mechanisms of acute pancreatitis
由: Laura I Cosen-Binker, et al.
出版: (2007-01-01)

Effects of nutrient metabolism on pancreatic β‐cell mass and function: Recent findings
由: Takuma Yasuda, et al.
出版: (2023-11-01)

Congenital Disorders of the Human Urinary Tract: Recent Insights From Genetic and Molecular Studies
由: Adrian S. Woolf, et al.
出版: (2019-04-01)

Reduced insulin exocytosis in human pancreatic β-cells with gene variants linked to type 2 diabetes.
由: Rosengren, A, et al.
出版: (2012)

Stepwise differentiation of functional pancreatic β cells from human pluripotent stem cells
由: Wenwen Jin, et al.
出版: (2022-08-01)

Argonaute2 mediates compensatory expansion of the pancreatic β cell.
由: Tattikota, S, et al.
出版: (2014)

Argonaute2 mediates compensatory expansion of the pancreatic β cell
由: Tattikota, S, et al.
出版: (2014)

The importance of context: uncovering species- and tissue-specific effects of genetic risk variants for type 2 diabetes
由: Thomsen, S, et al.
出版: (2016)

GLUT2 (SLC2A2) is not the principal glucose transporter in human pancreatic beta cells: implications for understanding genetic association signals at this locus.
由: McCulloch, L, et al.
出版: (2011)

GLUT2 (SLC2A2) is not the principal glucose transporter in human pancreatic beta cells: Implications for understanding genetic association signals at this locus
由: McCulloch, L, et al.
出版: (2011)

Genetic regulation of RNA splicing in human pancreatic islets
由: Goutham Atla, et al.
出版: (2022-09-01)

Recent insights on the genetics and epigenetics of endometriosis
由: Borghese, B, et al.
出版: (2016)

The Plasticity of Pancreatic β-Cells
由: Norikiyo Honzawa, et al.
出版: (2021-04-01)

Glucolipotoxicity in Pancreatic β-Cells
由: Ji-Won Kim, et al.
出版: (2011-10-01)

Correction: Stepwise differentiation of functional pancreatic β cells from human pluripotent stem cells
由: Wenwen Jin, et al.
出版: (2022-08-01)

Exocrine or endocrine? A circulating pancreatic elastase that regulates glucose homeostasis
由: Gloyn, A
出版: (2019)

Type 2 diabetes risk alleles in PAM impact insulin release from human pancreatic beta cells
由: Thomsen, S, et al.
出版: (2018)

RD Lawrence Lecture 2009. Old genes, new tricks: learning about blood glucose regulation from naturally occurring genetic variation in humans.
由: Gloyn, A
出版: (2009)

TGFβ Pathway Inhibition Redifferentiates Human Pancreatic Islet β Cells Expanded In Vitro.
由: Ginat Toren-Haritan, et al.
出版: (2015-01-01)

NEUROD2 function is dispensable for human pancreatic β cell specification
由: Perla Cota, et al.
出版: (2023-10-01)

Functional Genomics in Pancreatic β Cells: Recent Advances in Gene Deletion and Genome Editing Technologies for Diabetes Research
由: Ming Hu, et al.
出版: (2020-10-01)

Pancreatic stellate cells support human pancreatic β-cell viability in vitro and enhance survival of immunoisolated human islets exposed to cytokines
由: Tian Qin, et al.
出版: (2024-08-01)

Insights into the genetic risk factors for the development of pancreatic disease
由: Zachary Zator, et al.
出版: (2017-03-01)

The Genetic Facets of Dravet Syndrome: Recent Insights
由: Hinde El Mouhi, et al.
出版: (2024-04-01)

Disrupting the DREAM complex enables proliferation of adult human pancreatic β cells
由: Peng Wang, et al.
出版: (2022-08-01)

Pancreatic β Cell Mass Death
由: Salma Ibraheem Alsunousi, et al.
出版: (2016-04-01)

Biophysics and biochemistry of the pancreatic β-cell
由: Kelly, R
出版: (1989)

Genetic Background of β Thalassemia Modifier: Recent Update
由: Lantip Rujito, et al.
出版: (2018-07-01)

Loss of ZNF148 enhances insulin secretion in human pancreatic β cells
由: Eleonora de Klerk, et al.
出版: (2023-06-01)

Establishment of human pluripotent stem cell-derived pancreatic β-like cells in the mouse pancreas
由: Ma, Haiting, et al.
出版: (2018)

Production of Secretory Leucocyte Protease Inhibitor (SLPI) in Human Pancreatic β-Cells
由: Max Nyström, et al.
出版: (1999-01-01)