Membrane applications in autologous cell therapy
<p>Stem cell and cell therapies, particularly autologous cell therapies, are becoming a common practice. However, in order for these technologies to achieve wide-scale clinical application, the prohibitively high cost associated with these therapies must be addressed through creative engineeri...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
MDPI
2022
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| _version_ | 1826309585095360512 |
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| author | Martin, R Lei, R Zeng, Y Zhu, J Chang, H Ye, H Cui, Z |
| author_facet | Martin, R Lei, R Zeng, Y Zhu, J Chang, H Ye, H Cui, Z |
| author_sort | Martin, R |
| collection | OXFORD |
| description | <p>Stem cell and cell therapies, particularly autologous cell therapies, are becoming a common practice. However, in order for these technologies to achieve wide-scale clinical application, the prohibitively high cost associated with these therapies must be addressed through creative engineering. Membranes can be a disruptive technology to reshape the bioprocessing and manufacture of cellular products and significantly reduce the cost of autologous cell therapies. Examples of successful membrane applications include expansions of CAR-T cells, various human stem cells, and production of extracellular vesicles (EVs) using hollow fibre membrane bioreactors. Novel membranes with tailored functions and surface properties and novel membrane modules that can accommodate the changing needs for surface area and transport properties are to be developed to fulfil this key role.</p> |
| first_indexed | 2024-03-07T07:37:57Z |
| format | Journal article |
| id | oxford-uuid:69ef0d54-4235-4d02-acd5-6ee7ff2f11c1 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:37:57Z |
| publishDate | 2022 |
| publisher | MDPI |
| record_format | dspace |
| spelling | oxford-uuid:69ef0d54-4235-4d02-acd5-6ee7ff2f11c12023-03-23T09:24:42ZMembrane applications in autologous cell therapyJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:69ef0d54-4235-4d02-acd5-6ee7ff2f11c1EnglishSymplectic ElementsMDPI2022Martin, RLei, RZeng, YZhu, JChang, HYe, HCui, Z<p>Stem cell and cell therapies, particularly autologous cell therapies, are becoming a common practice. However, in order for these technologies to achieve wide-scale clinical application, the prohibitively high cost associated with these therapies must be addressed through creative engineering. Membranes can be a disruptive technology to reshape the bioprocessing and manufacture of cellular products and significantly reduce the cost of autologous cell therapies. Examples of successful membrane applications include expansions of CAR-T cells, various human stem cells, and production of extracellular vesicles (EVs) using hollow fibre membrane bioreactors. Novel membranes with tailored functions and surface properties and novel membrane modules that can accommodate the changing needs for surface area and transport properties are to be developed to fulfil this key role.</p> |
| spellingShingle | Martin, R Lei, R Zeng, Y Zhu, J Chang, H Ye, H Cui, Z Membrane applications in autologous cell therapy |
| title | Membrane applications in autologous cell therapy |
| title_full | Membrane applications in autologous cell therapy |
| title_fullStr | Membrane applications in autologous cell therapy |
| title_full_unstemmed | Membrane applications in autologous cell therapy |
| title_short | Membrane applications in autologous cell therapy |
| title_sort | membrane applications in autologous cell therapy |
| work_keys_str_mv | AT martinr membraneapplicationsinautologouscelltherapy AT leir membraneapplicationsinautologouscelltherapy AT zengy membraneapplicationsinautologouscelltherapy AT zhuj membraneapplicationsinautologouscelltherapy AT changh membraneapplicationsinautologouscelltherapy AT yeh membraneapplicationsinautologouscelltherapy AT cuiz membraneapplicationsinautologouscelltherapy |