LRP5 promotes adipose progenitor cell fitness and adipocyte insulin sensitivity

LRP5 promotes adipose progenitor cell fitness and adipocyte insulin sensitivity

Background: WNT signaling plays a key role in postnatal bone formation. Individuals with gain-of-function mutations in the WNT co-receptor LRP5 exhibit increased lower-body fat mass and potentially enhanced glucose metabolism, alongside high bone mass. However, the mechanisms by which LRP5 regulates...

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Bibliographische Detailangaben
Hauptverfasser:	Loh, NY, Vasan, SK, Rosoff, DB, Roberts, E, van Dam, AD, Verma, M, Phillips, D, Wesolowska-Andersen, A, Neville, MJ, Noordam, R, Ray, DW, Tobias, JH, Gregson, CL, Karpe, F, Christodoulides, C
Format:	Journal article
Sprache:	English
Veröffentlicht:	Nature Research 2025

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