Combined influence of B-cell receptor rearrangement and somatic hypermutation on B-cell class-switch fate in health and in chronic lymphocytic leukemia

Combined influence of B-cell receptor rearrangement and somatic hypermutation on B-cell class-switch fate in health and in chronic lymphocytic leukemia

A diverse B-cell receptor (BCR) repertoire is required to bind a wide range of antigens. BCRs are generated through genetic recombination and can be diversified through somatic hypermutation (SHM) or class-switch recombination (CSR). Patterns of repertoire diversity can vary substantially between di...

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Bibliographic Details
Main Authors:	Petrova, V, Muir, L, McKay, P, Vassiliou, G, Smith, K, Lyons, P, Russell, C, Anderson, C, Kellam, P, Bashford-Rogers, R
Format:	Journal article
Language:	English
Published:	Frontiers Media 2018

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