An open, randomized comparison of artesunate plus mefloquine vs. dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria in the Lao People's Democratic Republic (Laos).

An open, randomized comparison of artesunate plus mefloquine vs. dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria in the Lao People's Democratic Republic (Laos).

OBJECTIVE: To determine the efficacy and safety of oral dihydroartemisinin-piperaquine (DP, Artekin) in the treatment of uncomplicated Plasmodium falciparum malaria in southern Laos. METHODS: An open, randomized clinical trial of oral artesunate-mefloquine (AM) vs. DP in 220 patients with acute unco...

Full description

Bibliographic Details
Main Authors:	Mayxay, M, Thongpraseuth, V, Khanthavong, M, Lindeg?rdh, N, Barends, M, Keola, S, Pongvongsa, T, Phompida, S, Phetsouvanh, R, Stepniewska, K, White, N, Newton, P
Format:	Journal article
Language:	English
Published:	2006

Similar Items

A phase III, randomized, non-inferiority trial to assess the efficacy and safety of dihydroartemisinin-piperaquine in comparison with artesunate-mefloquine in patients with uncomplicated Plasmodium falciparum malaria in southern Laos.
by: Mayxay, M, et al.
Published: (2010)

Randomized comparison of chloroquine plus sulfadoxine-pyrimethamine versus artesunate plus mefloquine versus artemether-lumefantrine in the treatment of uncomplicated falciparum malaria in the Lao People's Democratic Republic.
by: Mayxay, M, et al.
Published: (2004)

Thiamin deficiency and uncomplicated falciparum malaria in Laos.
by: Mayxay, M, et al.
Published: (2007)

Diagnosis and management of malaria by rural community health providers in the Lao People's Democratic Republic (Laos).
by: Mayxay, M, et al.
Published: (2007)

Therapeutic efficacy of artemether-lumefantrine and artesunate-mefloquine for treatment of uncomplicated Plasmodium falciparum malaria in Luang Namtha Province, Lao People's Democratic Republic.
by: Stohrer, J, et al.
Published: (2004)

An open-label, randomised study of dihydroartemisinin-piperaquine versus artesunate-mefloquine for falciparum malaria in Asia
by: Valecha, N, et al.
Published: (2010)

An open-label, randomised study of dihydroartemisinin-piperaquine versus artesunate-mefloquine for falciparum malaria in Asia.
by: Valecha, N, et al.
Published: (2010)

Efficacy and effectiveness of dihydroartemisinin-piperaquine versus artesunate-mefloquine in falciparum malaria: an open-label randomised comparison.
by: Smithuis, F, et al.
Published: (2006)

Combined molecular and clinical assessment of Plasmodium falciparum antimalarial drug resistance in the Lao People's Democratic Republic (Laos).
by: Mayxay, M, et al.
Published: (2007)

A randomized comparison of oral chloroquine and sulfadoxine-pyrimethamine for the treatment of uncomplicated Plasmodium falciparum malaria in Laos.
by: Mayxay, M, et al.
Published: (2003)

Efficacy of artemether-lumefantrine, the nationally-recommended artemisinin combination for the treatment of uncomplicated falciparum malaria, in southern Laos.
by: Mayxay, M, et al.
Published: (2012)

In vitro antimalarial drug susceptibility and pfcrt mutation among fresh Plasmodium falciparum isolates from the Lao PDR (Laos).
by: Mayxay, M, et al.
Published: (2007)

Treatment response in Lao children with P-FalcimparumMalaria
by: Mayxay, M, et al.
Published: (2004)

Melioidosis and Pandora's box in the Lao People's Democratic Republic.
by: Phetsouvanh, R, et al.
Published: (2001)

Chloroquine versus sulfadoxine-pyrimethamine for treatment of Plasmodium falciparum malaria in Savannakhet Province, Lao People's Democratic Republic: an assessment of national antimalarial drug recommendations.
by: Mayxay, M, et al.
Published: (2003)

Short communication: An assessment of the use of malaria rapid tests by village health volunteers in rural Laos
by: Mayxay, M, et al.
Published: (2004)

Short communication: An assessment of the use of malaria rapid tests by village health volunteers in rural Laos.
by: Mayxay, M, et al.
Published: (2004)

No evidence for spread of Plasmodium falciparum artemisinin resistance to Savannakhet Province, Southern Laos.
by: Mayxay, M, et al.
Published: (2012)

Sporotrichosis, Plain of Jars, Lao People's Democratic Republic.
by: Newton, P, et al.
Published: (2005)

A randomized controlled trial of dihydroartemisinin-piperaquine, artesunate-mefloquine and extended artemether-lumefantrine treatments for malaria in pregnancy on the Thailand-Myanmar border.
by: Saito, M, et al.
Published: (2021)

Detection of Burkholderia pseudomallei in soil within the Lao People's Democratic Republic.
by: Wuthiekanun, V, et al.
Published: (2005)

Pharmacokinetics of dihydroartemisinin and piperaquine in pregnant and nonpregnant women with uncomplicated falciparum malaria.
by: Rijken, M, et al.
Published: (2011)

Population pharmacokinetics of dihydroartemisinin and piperaquine in pregnant and nonpregnant women with uncomplicated malaria.
by: Tarning, J, et al.
Published: (2012)

Population Pharmacokinetics of Dihydroartemisinin and Piperaquine in Pregnant and Nonpregnant Women with Uncomplicated Malaria
by: Tarning, J, et al.
Published: (2012)

Electrocardiographic safety evaluation of dihydroartemisinin piperaquine in the treatment of uncomplicated falciparum malaria.
by: Mytton, O, et al.
Published: (2007)

Population pharmacokinetics of piperaquine after two different treatment regimens of dihydroartemisinin piperaquine in patients with acute uncomplicated falciparum malaria in Thailand
by: Tarning, J, et al.
Published: (2007)

Efficacy and day 7 plasma piperaquine concentrations in African children treated for uncomplicated malaria with dihydroartemisinin-piperaquine
by: Zongo, I, et al.
Published: (2014)

Species Composition of Mosquitoes of Attapeu Province, Lao People's Democratic Republic
by: Vythilingam, I., et al.
Published: (2006)

Pharmacokinetics of dihydroartemisinin following oral artesunate treatment of pregnant women with acute uncomplicated falciparum malaria.
by: Mcgready, R, et al.
Published: (2006)

Artesunate and mefloquine in the treatment of uncomplicated multidrug-resistant hyperparasitaemic falciparum malaria.
by: Price, R, et al.
Published: (1998)

Melioidosis in the Lao People’s Democratic Republic
by: Dance, D, et al.
Published: (2018)

High throughput assay for the determination of piperaquine in plasma.
by: Lindeg?rdh, N, et al.
Published: (2005)

In vivo sensitivity monitoring of mefloquine monotherapy and artesunate-mefloquine combinations for the treatment of uncomplicated falciparum malaria in Thailand in 2003.
by: Ashley, E, et al.
Published: (2006)

Knowledge, attitudes, and practices on climate change and dengue in Lao People's Democratic Republic and Thailand
by: Rahman, MS, et al.
Published: (2020)

Efficacy and safety of dihydroartemisinin-piperaquine.
by: Myint, H, et al.
Published: (2007)

A randomized comparison of oral chloramphenicol versus ofloxacin in the treatment of uncomplicated typhoid fever in Laos.
by: Phongmany, S, et al.
Published: (2005)

Piperaquine concentration and malaria treatment outcomes in Ugandan children treated for severe malaria with intravenous Artesunate or quinine plus Dihydroartemisinin-Piperaquine
by: Byakika-Kibwika, P, et al.
Published: (2019)

Safety and efficacy of dihydroartemisinin/piperaquine (Artekin) for the treatment of uncomplicated Plasmodium falciparum malaria in Rwandan children.
by: Karema, C, et al.
Published: (2006)

Pharmacokinetic predictors for recurrent malaria after dihydroartemisinin-piperaquine treatment of uncomplicated malaria in Ugandan infants.
by: Creek, D, et al.
Published: (2013)

Investigation of recurrent melioidosis in Lao People's Democratic Republic by multilocus sequence typing
by: Rachlin, A, et al.
Published: (2016)