A mathematical model of tumour and blood pHe regulation: The HCO 3 -/CO 2 buffering system

Malignant tumours are characterised by a low, acidic extracellular pH (pHe) which facilitates invasion and metastasis. Previous research has proposed the potential benefits of manipulating systemic pHe, and recent experiments have highlighted the potential for buffer therapy to raise tumour pHe, pre...

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Bibliographic Details
Main Authors: Martin, N, Gaffney, E, Gatenby, R, Gillies, R, Robey, I, Maini, P
Format: Journal article
Language:English
Published: 2011