Target-specific requirements for enhancers of decapping in miRNA-mediated gene silencing.
microRNAs (miRNAs) silence gene expression by suppressing protein production and/or by promoting mRNA decay. To elucidate how silencing is accomplished, we screened an RNA interference library for suppressors of miRNA-mediated regulation in Drosophila melanogaster cells. In addition to proteins know...
Main Authors: | Eulalio, A, Rehwinkel, J, Stricker, M, Huntzinger, E, Yang, S, Doerks, T, Dorner, S, Bork, P, Boutros, M, Izaurralde, E |
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פורמט: | Journal article |
שפה: | English |
יצא לאור: |
2007
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פריטים דומים
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mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes.
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A crucial role for GW182 and the DCP1:DCP2 decapping complex in miRNA-mediated gene silencing.
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Deadenylation is a widespread effect of miRNA regulation.
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HPat a decapping activator interacting with the miRNA effector complex.
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MicroRNAs silence gene expression by repressing protein expression and/or by promoting mRNA decay.
מאת: Behm-Ansmant, I, et al.
יצא לאור: (2006)