Microcompartmentation of aldolase in Arabidopsis
<p>Understanding the internal organization of cells from the molecular up to organelle level is a current challenge for biology if we are to better comprehend the mechanisms by which cellular processes occur. A prevailing view of the cell interior is that biochemical reactions and molecular mo...
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| Format: | Thesis |
| Language: | English |
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2014
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| _version_ | 1797073693506011136 |
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| author | Garagounis, C |
| author2 | Sweetlove, L |
| author_facet | Sweetlove, L Garagounis, C |
| author_sort | Garagounis, C |
| collection | OXFORD |
| description | <p>Understanding the internal organization of cells from the molecular up to organelle level is a current challenge for biology if we are to better comprehend the mechanisms by which cellular processes occur. A prevailing view of the cell interior is that biochemical reactions and molecular movements are dominated by random diffusion. However, in addition to being compartmented into organelles, cells may well be organized at a finer level. Proteins may localise to specific areas within sub-cellular compartments, by associating with each other, the cytoskeleton and organelle membranes. Thus giving rise to distinct microcompartments. Considerable <em>in vitro</em> evidence exists for such interactions between enzymes and larger cellular components. This strengthens the idea that cells may be microcompartmented. However, little <em>in vivo</em> evidence supports this hypothesis, especially in plants. As a test-case for the concept of microcompartmentation this project investigated the sub-cellular distribution of the glycolytic enzyme fructose-bisphosphate aldolase in <em>Arabidopsis thaliana</em>; the ultimate aim being to establish whether it is microcompartmented <em>in vivo</em> and, further, to test the potential function(s) of such microcompartmentation.</p> |
| first_indexed | 2024-03-06T23:25:44Z |
| format | Thesis |
| id | oxford-uuid:6a4e0671-ee0d-4303-9118-d1f34a7ce06c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:25:44Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | oxford-uuid:6a4e0671-ee0d-4303-9118-d1f34a7ce06c2022-03-26T18:56:36ZMicrocompartmentation of aldolase in ArabidopsisThesishttp://purl.org/coar/resource_type/c_db06uuid:6a4e0671-ee0d-4303-9118-d1f34a7ce06cPlant SciencesCell Biology (plants)BiochemistryBiologyLife SciencesMetabolismEnglishOxford University Research Archive - Valet2014Garagounis, CSweetlove, LMoore, I<p>Understanding the internal organization of cells from the molecular up to organelle level is a current challenge for biology if we are to better comprehend the mechanisms by which cellular processes occur. A prevailing view of the cell interior is that biochemical reactions and molecular movements are dominated by random diffusion. However, in addition to being compartmented into organelles, cells may well be organized at a finer level. Proteins may localise to specific areas within sub-cellular compartments, by associating with each other, the cytoskeleton and organelle membranes. Thus giving rise to distinct microcompartments. Considerable <em>in vitro</em> evidence exists for such interactions between enzymes and larger cellular components. This strengthens the idea that cells may be microcompartmented. However, little <em>in vivo</em> evidence supports this hypothesis, especially in plants. As a test-case for the concept of microcompartmentation this project investigated the sub-cellular distribution of the glycolytic enzyme fructose-bisphosphate aldolase in <em>Arabidopsis thaliana</em>; the ultimate aim being to establish whether it is microcompartmented <em>in vivo</em> and, further, to test the potential function(s) of such microcompartmentation.</p> |
| spellingShingle | Plant Sciences Cell Biology (plants) Biochemistry Biology Life Sciences Metabolism Garagounis, C Microcompartmentation of aldolase in Arabidopsis |
| title | Microcompartmentation of aldolase in Arabidopsis |
| title_full | Microcompartmentation of aldolase in Arabidopsis |
| title_fullStr | Microcompartmentation of aldolase in Arabidopsis |
| title_full_unstemmed | Microcompartmentation of aldolase in Arabidopsis |
| title_short | Microcompartmentation of aldolase in Arabidopsis |
| title_sort | microcompartmentation of aldolase in arabidopsis |
| topic | Plant Sciences Cell Biology (plants) Biochemistry Biology Life Sciences Metabolism |
| work_keys_str_mv | AT garagounisc microcompartmentationofaldolaseinarabidopsis |