Elucidating the function of non catalytic domains of collagenases and aggrecanases.

Metalloproteinases that degrade extracellular matrix molecules play important roles in development and progression of various diseases. Among them, collagenases are unique as they have an ability to degrade triple helical interstitial collagens into 3/4 and 1/4 fragments, a crucial step for collagen...

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Bibliographic Details
Main Authors: Nagase, H, Fushimi, K
Format: Journal article
Language:English
Published: 2008