The adenomatous polyposis coli (APC) tumour suppressor--genetics, function and disease.

The adenomatous polyposis coli (APC) tumour suppressor--genetics, function and disease.

Mutations in the adenomatous polyposis coli (APC) gene are the basis of familial adenomatous polyposis and the majority of sporadic colorectal cancer. APC is expressed in a wide variety of tissues, interacts with the cytoskeleton, is involved in regulating levels of beta-catenin and, most recently,...

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Dettagli Bibliografici
Autori principali:	Sieber, O, Tomlinson, I, Lamlum, H
Natura:	Journal article
Lingua:	English
Pubblicazione:	2000

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