The adenomatous polyposis coli (APC) tumour suppressor--genetics, function and disease.

The adenomatous polyposis coli (APC) tumour suppressor--genetics, function and disease.

Mutations in the adenomatous polyposis coli (APC) gene are the basis of familial adenomatous polyposis and the majority of sporadic colorectal cancer. APC is expressed in a wide variety of tissues, interacts with the cytoskeleton, is involved in regulating levels of beta-catenin and, most recently,...

Podrobná bibliografie
Hlavní autoři:	Sieber, O, Tomlinson, I, Lamlum, H
Médium:	Journal article
Jazyk:	English
Vydáno:	2000

Podobné jednotky

Evidence for genetic predisposition to desmoid tumours in familial adenomatous polyposis independent of the germline APC mutation.
Autor: Sturt, N, a další
Vydáno: (2004)

Whole-gene APC deletions cause classical familial adenomatous polyposis, but not attenuated polyposis or "multiple" colorectal adenomas
Autor: Sieber, O, a další
Vydáno: (2002)

Whole-gene APC deletions cause classical familial adenomatous polyposis, but not attenuated polyposis or "multiple" colorectal adenomas.
Autor: Sieber, O, a další
Vydáno: (2002)

Functional comparison of human Adenomatous Polyposis Coli (APC) and APC-like in targeting beta-catenin for degradation
Autor: Schneikert, Jean, a další
Vydáno: (2013)

The Tumor Suppressor <i>Adenomatous Polyposis Coli (apc)</i> Is Required for Neural Crest-Dependent Craniofacial Development in Zebrafish
Autor: Xiaolei Liu, a další
Vydáno: (2023-06-01)

Familial adenomatous polyposis (FAP) and its gene, APC.
Autor: Bodmer, W
Vydáno: (1999)

The in vivo rate of somatic adenomatous polyposis coli mutation.
Autor: Hornsby, C, a další
Vydáno: (2008)

The clonal origin of human tumours: is familial adenomatous polyposis (FAP) different?
Autor: Leedham, S, a další
Vydáno: (2006)

Molecular analysis of APC mutations in familial adenomatous polyposis and sporadic colon carcinomas.
Autor: Cottrell, S, a další
Vydáno: (1992)

Identification of an APC Variant in a Patient with Clinical Attenuated Familial Adenomatous Polyposis
Autor: Andrew T. Schlussel, a další
Vydáno: (2014-01-01)

Pathogenic <i>APC</i> Variants in Latvian Familial Adenomatous Polyposis Patients
Autor: Zanda Daneberga, a další
Vydáno: (2019-09-01)

T cell migration and effector function differences in familial adenomatous polyposis patients with APC gene mutations
Autor: Céline Cuche, a další
Vydáno: (2023-07-01)

The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis.
Autor: Lamlum, H, a další
Vydáno: (1999)

Familial Adenomatous Polyposis: Analysis of Genetic Instability of Microsatellites Loci and Genetic Alternations of Tumor Suppressor Genes
Autor: Vesna Hadžiavdić, a další
Vydáno: (2008-05-01)

Coinheritance of germline mutations in APC and MUTYH genes defines the clinical outcome of adenomatous polyposis syndromes
Autor: Giovanna Forte, a další
Vydáno: (2023-07-01)

Identification of a novel CNV at the APC gene in a Chinese family with familial adenomatous polyposis
Autor: Juyi Li, a další
Vydáno: (2023-07-01)

Multiple colorectal adenomas, classic adenomatous polyposis, and germ-line mutations in MYH.
Autor: Sieber, O, a další
Vydáno: (2003)

Multiple Adenomatous Duodenal Polyposis
Autor: Zdena Zádorová, a další
Vydáno: (2013-01-01)

Familial Adenomatous Polyposis: An Uncommon Autosomal Genetic Condition
Autor: Simran Khan, a další
Vydáno: (2024-12-01)

A novel exon duplication event leading to a truncating germ-line mutation of the APC gene in a familial adenomatous polyposis family.
Autor: McCart, A, a další
Vydáno: (2006)

Identification of a novel germline APC N-terminal pathogenic variant associated with attenuated familial adenomatous polyposis
Autor: Giovanna Forte, a další
Vydáno: (2024-11-01)

Promoter hypermethylation leads to decreased APC mRNA expression in familial polyposis and sporadic colorectal tumours, but does not substitute for truncating mutations.
Autor: Segditsas, S, a další
Vydáno: (2008)

Disease severity and genetic pathways in attenuated familial adenomatous polyposis vary greatly but depend on the site of the germline mutation.
Autor: Sieber, O, a další
Vydáno: (2006)

Genomic insights into familial adenomatous polyposis: unraveling a rare case with whole APC gene deletion and intellectual disability
Autor: Hiroki Tanabe, a další
Vydáno: (2024-03-01)

Mucinous colorectal adenocarcinoma in a patient with familial adenomatous polyposis and melanosis coli
Autor: Yinji Zhou, a další
Vydáno: (2023-12-01)

Effect of Adenomatous Polyposis Coli Loss on Tumorigenic Potential in Pancreatic Ductal Adenocarcinoma
Autor: Jennifer M. Cole, a další
Vydáno: (2019-09-01)

Our Clinical and Surgical Treatment Results in Patients with Familial Adenomatous Polyposis Coli
Autor: Ramazan GÜNDOĞDU, a další
Vydáno: (2021-12-01)

Attenuated familial adenomatous polyposis: results from an international collaborative study.
Autor: Knudsen, A, a další
Vydáno: (2010)

A Two Generation of Familial Adenomatous Polyposis
Autor: Lily Chandrawati, a další
Vydáno: (2020-07-01)

Explaining differences in the severity of familial adenomatous polyposis and the search for modifier genes.
Autor: Houlston, R, a další
Vydáno: (2001)

MSH2 and APC mutated mouse models closely mimic the differences between hereditary nonpolyposis colorectal cancer and familial adenomatous polyposis
Autor: B. Oliveira Rocha, a další
Vydáno: (2023-03-01)

Mutation cluster region, association between germline and somatic mutations and genotype-phenotype correlation in upper gastrointestinal familial adenomatous polyposis.
Autor: Groves, C, a další
Vydáno: (2002)

De novo familial adenomatous polyposis with germline double heterozygosity of APC/BRCA2: a case report and literature review
Autor: Tian-Qi Zhang, a další
Vydáno: (2025-02-01)

A Novel Germline Mutation in Exon 15 of the APC Gene in Attenuated Familial Adenomatous Polyposis: A Report of Two Cases
Vydáno: (2013-01-01)

Germline epimutations of APC are not associated with inherited colorectal polyposis.
Autor: Hitchins, M, a další
Vydáno: (2006)

Vaccines for cancer interception in familial adenomatous polyposis
Autor: David E. Johnson, a další
Vydáno: (2025-01-01)

Familial adenomatous polyposis: a case report
Autor: Endeshaw Asaye Kindie, a další
Vydáno: (2024-09-01)

A 16-year-old girl with familial adenomatous polyposis coli misdiagnosed as hemorrhoids
Autor: Taifu Xiao, a další
Vydáno: (2023-11-01)

Variability in the severity of colonic disease in familial adenomatous polyposis results from differences in tumour initiation rather than progression and depends relatively little on patient age.
Autor: Crabtree, MD, a další
Vydáno: (2001)

Familial adenomatous polyposis and the small bowel: a loco-regional review and current management strategies.
Autor: Will, O, a další
Vydáno: (2008)