The adenomatous polyposis coli (APC) tumour suppressor--genetics, function and disease.
Mutations in the adenomatous polyposis coli (APC) gene are the basis of familial adenomatous polyposis and the majority of sporadic colorectal cancer. APC is expressed in a wide variety of tissues, interacts with the cytoskeleton, is involved in regulating levels of beta-catenin and, most recently,...
Main Authors: | Sieber, O, Tomlinson, I, Lamlum, H |
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Format: | Journal article |
Language: | English |
Published: |
2000
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