The adenomatous polyposis coli (APC) tumour suppressor--genetics, function and disease.

The adenomatous polyposis coli (APC) tumour suppressor--genetics, function and disease.

Mutations in the adenomatous polyposis coli (APC) gene are the basis of familial adenomatous polyposis and the majority of sporadic colorectal cancer. APC is expressed in a wide variety of tissues, interacts with the cytoskeleton, is involved in regulating levels of beta-catenin and, most recently,...

Mô tả đầy đủ

Chi tiết về thư mục
Những tác giả chính:	Sieber, O, Tomlinson, I, Lamlum, H
Định dạng:	Journal article
Ngôn ngữ:	English
Được phát hành:	2000

Những quyển sách tương tự

Adenomatous Polyposis Coli (APC) in cell migration
Bằng: Xingyuan Fang, et al.
Được phát hành: (2022-06-01)

Evidence for genetic predisposition to desmoid tumours in familial adenomatous polyposis independent of the germline APC mutation.
Bằng: Sturt, N, et al.
Được phát hành: (2004)

Whole-gene APC deletions cause classical familial adenomatous polyposis, but not attenuated polyposis or "multiple" colorectal adenomas
Bằng: Sieber, O, et al.
Được phát hành: (2002)

Whole-gene APC deletions cause classical familial adenomatous polyposis, but not attenuated polyposis or "multiple" colorectal adenomas.
Bằng: Sieber, O, et al.
Được phát hành: (2002)

Functional comparison of human Adenomatous Polyposis Coli (APC) and APC-like in targeting beta-catenin for degradation
Bằng: Schneikert, Jean, et al.
Được phát hành: (2013)

Functional comparison of human adenomatous polyposis coli (APC) and APC-like in targeting beta-catenin for degradation.
Bằng: Jean Schneikert, et al.
Được phát hành: (2013-01-01)

The Tumor Suppressor <i>Adenomatous Polyposis Coli (apc)</i> Is Required for Neural Crest-Dependent Craniofacial Development in Zebrafish
Bằng: Xiaolei Liu, et al.
Được phát hành: (2023-06-01)

The Adenomatous polyposis coli tumour suppressor is essential for Axin complex assembly and function and opposes Axin's interaction with Dishevelled
Bằng: Carolina Mendoza-Topaz, et al.
Được phát hành: (2011-01-01)

Familial adenomatous polyposis (FAP) and its gene, APC.
Bằng: Bodmer, W
Được phát hành: (1999)

A metabolic switch controls intestinal differentiation downstream of Adenomatous polyposis coli (APC)
Bằng: Imelda T Sandoval, et al.
Được phát hành: (2017-04-01)

The in vivo rate of somatic adenomatous polyposis coli mutation.
Bằng: Hornsby, C, et al.
Được phát hành: (2008)

Wild-type APC Influences the Severity of Familial Adenomatous Polyposis
Bằng: Krzysztof Flisikowski, et al.
Được phát hành: (2022-01-01)

Familial adenomatous polyposis coli
Bằng: K Boeren, et al.
Được phát hành: (2011-03-01)

The clinical significance of adenomatous polyposis coli (APC) and catenin Beta 1 (CTNNB1) genetic aberrations in patients with melanoma
Bằng: Georgia Sofia Karachaliou, et al.
Được phát hành: (2022-01-01)

Curated multiple sequence alignment for the Adenomatous Polyposis Coli (APC) gene and accuracy of in silico pathogenicity predictions.
Bằng: Alexander D Karabachev, et al.
Được phát hành: (2020-01-01)

The fluctuation of APC gene in WNT signaling with adenine deletion of adenomatous polyposis coli, is associated in colorectal cancer
Bằng: Seyedeh Elham Norollahi, et al.
Được phát hành: (2020-04-01)

The clonal origin of human tumours: is familial adenomatous polyposis (FAP) different?
Bằng: Leedham, S, et al.
Được phát hành: (2006)

Molecular analysis of APC mutations in familial adenomatous polyposis and sporadic colon carcinomas.
Bằng: Cottrell, S, et al.
Được phát hành: (1992)

Identification of an APC Variant in a Patient with Clinical Attenuated Familial Adenomatous Polyposis
Bằng: Andrew T. Schlussel, et al.
Được phát hành: (2014-01-01)

Pathogenic <i>APC</i> Variants in Latvian Familial Adenomatous Polyposis Patients
Bằng: Zanda Daneberga, et al.
Được phát hành: (2019-09-01)

T cell migration and effector function differences in familial adenomatous polyposis patients with APC gene mutations
Bằng: Céline Cuche, et al.
Được phát hành: (2023-07-01)

The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis.
Bằng: Lamlum, H, et al.
Được phát hành: (1999)

Adenomatous polyposis coli in cancer and therapeutic implications
Bằng: Olivia Noe, et al.
Được phát hành: (2021-06-01)

Modeling APC mutagenesis and familial adenomatous polyposis using human iPS cells.
Bằng: Cesar A Sommer, et al.
Được phát hành: (2018-01-01)

Ubiquitous neurocognitive dysfunction in familial adenomatous polyposis: proof-of-concept of the role of APC protein in neurocognitive function
Bằng: Marcia Roxana Cruz-Correa, et al.
Được phát hành: (2020-02-01)

Identification of mutation in 3'-end of exon 15 of APC gene in familial adenomatous polyposis patients
Bằng: Habibollahi H, et al.
Được phát hành: (2020-02-01)

Familial Adenomatous Polyposis: Analysis of Genetic Instability of Microsatellites Loci and Genetic Alternations of Tumor Suppressor Genes
Bằng: Vesna Hadžiavdić, et al.
Được phát hành: (2008-05-01)

Coinheritance of germline mutations in APC and MUTYH genes defines the clinical outcome of adenomatous polyposis syndromes
Bằng: Giovanna Forte, et al.
Được phát hành: (2023-07-01)

Identification of a novel CNV at the APC gene in a Chinese family with familial adenomatous polyposis
Bằng: Juyi Li, et al.
Được phát hành: (2023-07-01)

Familial adenomatous polyposis
Bằng: Rozen Paul, et al.
Được phát hành: (2009-10-01)

Unresectable Desmoid Tumours Causing Obstructive Uropathy in Familial Adenomatous Polyposis
Bằng: Jia Lin Soon, et al.
Được phát hành: (2005-07-01)

Oncogenic mutations in adenomatous polyposis coli (Apc) activate mechanistic target of rapamycin complex 1 (mTORC1) in mice and zebrafish
Bằng: Alexander J. Valvezan, et al.
Được phát hành: (2014-01-01)

Adenomatous Polyposis Coli Mutation Leads to Myopia Development in Mice.
Bằng: Zhen Liu, et al.
Được phát hành: (2015-01-01)

Multiple colorectal adenomas, classic adenomatous polyposis, and germ-line mutations in MYH.
Bằng: Sieber, O, et al.
Được phát hành: (2003)

A novel exon duplication event leading to a truncating germ-line mutation of the APC gene in a familial adenomatous polyposis family.
Bằng: McCart, A, et al.
Được phát hành: (2006)

Promoter hypermethylation leads to decreased APC mRNA expression in familial polyposis and sporadic colorectal tumours, but does not substitute for truncating mutations.
Bằng: Segditsas, S, et al.
Được phát hành: (2008)

Multiple Adenomatous Duodenal Polyposis
Bằng: Zdena Zádorová, et al.
Được phát hành: (2013-01-01)

Familial Adenomatous Polyposis: An Uncommon Autosomal Genetic Condition
Bằng: Simran Khan, et al.
Được phát hành: (2024-12-01)

Familial Adenomatous Polyposis (FAP) and Other Polyposis Syndromes
Bằng: Scott Rodney J
Được phát hành: (2003-12-01)

Identification of a novel germline APC N-terminal pathogenic variant associated with attenuated familial adenomatous polyposis
Bằng: Giovanna Forte, et al.
Được phát hành: (2024-11-01)