Memory and the lifespan of human T lymphocytes.
The properties of human CD45RA and CD45R0 T cells are described. CD45R0 cells respond to recall antigens and provide help for B lymphocytes. They produce a wide variety of cytokines including IL-2, IL-4 and IFN-gamma. CD45RA T cells respond poorly to recall antigens and produce mainly IL-2. The phen...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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1993
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| _version_ | 1826277276894887936 |
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| author | Beverley, P Michie, C Young, J |
| author_facet | Beverley, P Michie, C Young, J |
| author_sort | Beverley, P |
| collection | OXFORD |
| description | The properties of human CD45RA and CD45R0 T cells are described. CD45R0 cells respond to recall antigens and provide help for B lymphocytes. They produce a wide variety of cytokines including IL-2, IL-4 and IFN-gamma. CD45RA T cells respond poorly to recall antigens and produce mainly IL-2. The phenotype of CD45R0 cells suggests that they may be in cycle and in vivo data shows that they have a short lifespan while CD45RA cells are long lived. The lineage relationship of the two subsets is not clear but in vivo and in vitro evidence suggests bidirectional conversion between CD45RA and CD45R0 phenotypes. |
| first_indexed | 2024-03-06T23:26:29Z |
| format | Journal article |
| id | oxford-uuid:6a894524-d3e7-49a4-b4ac-b83c96069815 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:26:29Z |
| publishDate | 1993 |
| record_format | dspace |
| spelling | oxford-uuid:6a894524-d3e7-49a4-b4ac-b83c960698152022-03-26T18:58:07ZMemory and the lifespan of human T lymphocytes.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:6a894524-d3e7-49a4-b4ac-b83c96069815EnglishSymplectic Elements at Oxford1993Beverley, PMichie, CYoung, JThe properties of human CD45RA and CD45R0 T cells are described. CD45R0 cells respond to recall antigens and provide help for B lymphocytes. They produce a wide variety of cytokines including IL-2, IL-4 and IFN-gamma. CD45RA T cells respond poorly to recall antigens and produce mainly IL-2. The phenotype of CD45R0 cells suggests that they may be in cycle and in vivo data shows that they have a short lifespan while CD45RA cells are long lived. The lineage relationship of the two subsets is not clear but in vivo and in vitro evidence suggests bidirectional conversion between CD45RA and CD45R0 phenotypes. |
| spellingShingle | Beverley, P Michie, C Young, J Memory and the lifespan of human T lymphocytes. |
| title | Memory and the lifespan of human T lymphocytes. |
| title_full | Memory and the lifespan of human T lymphocytes. |
| title_fullStr | Memory and the lifespan of human T lymphocytes. |
| title_full_unstemmed | Memory and the lifespan of human T lymphocytes. |
| title_short | Memory and the lifespan of human T lymphocytes. |
| title_sort | memory and the lifespan of human t lymphocytes |
| work_keys_str_mv | AT beverleyp memoryandthelifespanofhumantlymphocytes AT michiec memoryandthelifespanofhumantlymphocytes AT youngj memoryandthelifespanofhumantlymphocytes |