The mitochondrial cytochrome c N-terminal region is critical for maturation by holocytochrome c synthase.

The covalent attachment of heme to mitochondrial cytochrome c is catalysed by holocytochrome c synthase (HCCS, also called heme lyase). How HCCS functions and recognises the substrate apocytochrome is unknown. Here we have examined HCCS recognition of a chimeric substrate comprising a short mitochon...

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Bibliographic Details
Main Authors: Stevens, J, Zhang, Y, Muthuvel, G, Sam, K, Allen, J, Ferguson, S
Format: Journal article
Language:English
Published: 2011

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