Structure-based design and synthesis of potent, ethylenediamine-based, mammalian farnesyltransferase inhibitors as anticancer agents.

Structure-based design and synthesis of potent, ethylenediamine-based, mammalian farnesyltransferase inhibitors as anticancer agents.

A potent class of anticancer, human farnesyltransferase (hFTase) inhibitors has been identified by "piggy-backing" on potent, antimalarial inhibitors of Plasmodium falciparum farnesyltransferase (PfFTase). On the basis of a 4-fold substituted ethylenediamine scaffold, the inhibitors are st...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Fletcher, S, Keaney, E, Cummings, C, Blaskovich, M, Hast, M, Glenn, M, Chang, S, Bucher, C, Floyd, R, Katt, W, Gelb, M, Van Voorhis, W, Beese, L, Sebti, S, Hamilton, A
Format: Journal article
Sprache:English
Veröffentlicht: 2010

Ähnliche Einträge

Ähnliche Einträge