Structure-based design and synthesis of potent, ethylenediamine-based, mammalian farnesyltransferase inhibitors as anticancer agents.
A potent class of anticancer, human farnesyltransferase (hFTase) inhibitors has been identified by "piggy-backing" on potent, antimalarial inhibitors of Plasmodium falciparum farnesyltransferase (PfFTase). On the basis of a 4-fold substituted ethylenediamine scaffold, the inhibitors are st...
Үндсэн зохиолчид: | Fletcher, S, Keaney, E, Cummings, C, Blaskovich, M, Hast, M, Glenn, M, Chang, S, Bucher, C, Floyd, R, Katt, W, Gelb, M, Van Voorhis, W, Beese, L, Sebti, S, Hamilton, A |
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Формат: | Journal article |
Хэл сонгох: | English |
Хэвлэсэн: |
2010
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