Investigating the evidence of behavioral, cognitive, and psychiatric endophenotypes in autism: A systematic review.
Substantial evidence indicates that parents of autistic individuals often display milder forms of autistic traits referred to as the broader autism phenotype (BAP). To determine if discrete endophenotypes of autism can be identified, we reviewed the literature to assess the evidence of behavioral, c...
| Main Authors: | , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
Hindawi
2017
|
| _version_ | 1797073869093208064 |
|---|---|
| author | Ruparelia, K Manji, K Abubakar, A Newton, C |
| author_facet | Ruparelia, K Manji, K Abubakar, A Newton, C |
| author_sort | Ruparelia, K |
| collection | OXFORD |
| description | Substantial evidence indicates that parents of autistic individuals often display milder forms of autistic traits referred to as the broader autism phenotype (BAP). To determine if discrete endophenotypes of autism can be identified, we reviewed the literature to assess the evidence of behavioral, cognitive, and psychiatric profiles of the BAP. A systematic review was conducted using EMBASE, MEDLINE, PsycINFO, PsycEXTRA, and Global Health. Sixty papers met our inclusion criteria and results are discussed according to the proportion of studies that yield significant deficits per domain. The behavioral, cognitive, and psychiatric endophenotypes in parents of autistic probands are still not clarified; however, evidence suggests mild social/communication deficits, rigid/aloof personality traits, and pragmatic language difficulties as the most useful sociobehavioral candidate endophenotype traits. The existence of deficits in the cognitive domain does suggest familial vulnerability for autism. Furthermore, increased depressed mood and anxiety can also be useful markers; however, findings should be interpreted with caution because of the small number of studies in such heterogeneously broad domains and several methodological limitations. |
| first_indexed | 2024-03-06T23:28:07Z |
| format | Journal article |
| id | oxford-uuid:6b1b807f-743a-489b-a933-b81968b63711 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:28:07Z |
| publishDate | 2017 |
| publisher | Hindawi |
| record_format | dspace |
| spelling | oxford-uuid:6b1b807f-743a-489b-a933-b81968b637112022-03-26T19:01:35ZInvestigating the evidence of behavioral, cognitive, and psychiatric endophenotypes in autism: A systematic review.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:6b1b807f-743a-489b-a933-b81968b63711EnglishSymplectic Elements at OxfordHindawi2017Ruparelia, KManji, KAbubakar, ANewton, CSubstantial evidence indicates that parents of autistic individuals often display milder forms of autistic traits referred to as the broader autism phenotype (BAP). To determine if discrete endophenotypes of autism can be identified, we reviewed the literature to assess the evidence of behavioral, cognitive, and psychiatric profiles of the BAP. A systematic review was conducted using EMBASE, MEDLINE, PsycINFO, PsycEXTRA, and Global Health. Sixty papers met our inclusion criteria and results are discussed according to the proportion of studies that yield significant deficits per domain. The behavioral, cognitive, and psychiatric endophenotypes in parents of autistic probands are still not clarified; however, evidence suggests mild social/communication deficits, rigid/aloof personality traits, and pragmatic language difficulties as the most useful sociobehavioral candidate endophenotype traits. The existence of deficits in the cognitive domain does suggest familial vulnerability for autism. Furthermore, increased depressed mood and anxiety can also be useful markers; however, findings should be interpreted with caution because of the small number of studies in such heterogeneously broad domains and several methodological limitations. |
| spellingShingle | Ruparelia, K Manji, K Abubakar, A Newton, C Investigating the evidence of behavioral, cognitive, and psychiatric endophenotypes in autism: A systematic review. |
| title | Investigating the evidence of behavioral, cognitive, and psychiatric endophenotypes in autism: A systematic review. |
| title_full | Investigating the evidence of behavioral, cognitive, and psychiatric endophenotypes in autism: A systematic review. |
| title_fullStr | Investigating the evidence of behavioral, cognitive, and psychiatric endophenotypes in autism: A systematic review. |
| title_full_unstemmed | Investigating the evidence of behavioral, cognitive, and psychiatric endophenotypes in autism: A systematic review. |
| title_short | Investigating the evidence of behavioral, cognitive, and psychiatric endophenotypes in autism: A systematic review. |
| title_sort | investigating the evidence of behavioral cognitive and psychiatric endophenotypes in autism a systematic review |
| work_keys_str_mv | AT rupareliak investigatingtheevidenceofbehavioralcognitiveandpsychiatricendophenotypesinautismasystematicreview AT manjik investigatingtheevidenceofbehavioralcognitiveandpsychiatricendophenotypesinautismasystematicreview AT abubakara investigatingtheevidenceofbehavioralcognitiveandpsychiatricendophenotypesinautismasystematicreview AT newtonc investigatingtheevidenceofbehavioralcognitiveandpsychiatricendophenotypesinautismasystematicreview |