Response to malnutrition treatment in low weight-for-age children: secondary analyses of children 6–59 months in the ComPAS cluster randomized controlled trial
Weight-for-age z-score (WAZ) is not currently an admission criterion to therapeutic feeding programs, and children with low WAZ at high risk of mortality may not be admitted. We conducted a secondary analysis of RCT data to assess response to treatment according to WAZ and mid-upper arm circumferenc...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
MDPI
2021
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| _version_ | 1826277392380854272 |
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| author | Bailey, J Lelijveld, N Khara, T Dolan, C Stobaugh, H Sadler, K Lako, RL Briend, A Opondo, C Kerac, M Myatt, M |
| author_facet | Bailey, J Lelijveld, N Khara, T Dolan, C Stobaugh, H Sadler, K Lako, RL Briend, A Opondo, C Kerac, M Myatt, M |
| author_sort | Bailey, J |
| collection | OXFORD |
| description | Weight-for-age z-score (WAZ) is not currently an admission criterion to therapeutic feeding programs, and children with low WAZ at high risk of mortality may not be admitted. We conducted a secondary analysis of RCT data to assess response to treatment according to WAZ and mid-upper arm circumference (MUAC) and type of feeding protocol given: a simplified, combined protocol for severe and moderate acute malnutrition (SAM and MAM) vs. standard care that treats SAM and MAM, separately. Children with a moderately low MUAC (11.5–12.5 cm) and a severely low WAZ (<−3) respond similarly to treatment in terms of both weight and MUAC gain on either 2092 kJ (500 kcal)/day of therapeutic or supplementary food. Children with a severely low MUAC (<11.5 cm), with/without a severely low WAZ (<−3), have similar recovery with the combined protocol or standard treatment, though WAZ gain may be slower in the combined protocol. A limitation is this analysis was not powered for these sub-groups specifically. Adding WAZ < −3 as an admission criterion for therapeutic feeding programs admitting children with MUAC and/or oedema may help programs target high-risk children who can benefit from treatment. Future work should evaluate the optimal treatment protocol for children with a MUAC < 11.5 and/or WAZ < −3.0. |
| first_indexed | 2024-03-06T23:28:12Z |
| format | Journal article |
| id | oxford-uuid:6b208c87-2308-42a9-bc88-92e72faf4ffb |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:28:12Z |
| publishDate | 2021 |
| publisher | MDPI |
| record_format | dspace |
| spelling | oxford-uuid:6b208c87-2308-42a9-bc88-92e72faf4ffb2022-03-26T19:01:49ZResponse to malnutrition treatment in low weight-for-age children: secondary analyses of children 6–59 months in the ComPAS cluster randomized controlled trialJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:6b208c87-2308-42a9-bc88-92e72faf4ffbEnglishSymplectic ElementsMDPI2021Bailey, JLelijveld, NKhara, TDolan, CStobaugh, HSadler, KLako, RLBriend, AOpondo, CKerac, MMyatt, MWeight-for-age z-score (WAZ) is not currently an admission criterion to therapeutic feeding programs, and children with low WAZ at high risk of mortality may not be admitted. We conducted a secondary analysis of RCT data to assess response to treatment according to WAZ and mid-upper arm circumference (MUAC) and type of feeding protocol given: a simplified, combined protocol for severe and moderate acute malnutrition (SAM and MAM) vs. standard care that treats SAM and MAM, separately. Children with a moderately low MUAC (11.5–12.5 cm) and a severely low WAZ (<−3) respond similarly to treatment in terms of both weight and MUAC gain on either 2092 kJ (500 kcal)/day of therapeutic or supplementary food. Children with a severely low MUAC (<11.5 cm), with/without a severely low WAZ (<−3), have similar recovery with the combined protocol or standard treatment, though WAZ gain may be slower in the combined protocol. A limitation is this analysis was not powered for these sub-groups specifically. Adding WAZ < −3 as an admission criterion for therapeutic feeding programs admitting children with MUAC and/or oedema may help programs target high-risk children who can benefit from treatment. Future work should evaluate the optimal treatment protocol for children with a MUAC < 11.5 and/or WAZ < −3.0. |
| spellingShingle | Bailey, J Lelijveld, N Khara, T Dolan, C Stobaugh, H Sadler, K Lako, RL Briend, A Opondo, C Kerac, M Myatt, M Response to malnutrition treatment in low weight-for-age children: secondary analyses of children 6–59 months in the ComPAS cluster randomized controlled trial |
| title | Response to malnutrition treatment in low weight-for-age children: secondary analyses of children 6–59 months in the ComPAS cluster randomized controlled trial |
| title_full | Response to malnutrition treatment in low weight-for-age children: secondary analyses of children 6–59 months in the ComPAS cluster randomized controlled trial |
| title_fullStr | Response to malnutrition treatment in low weight-for-age children: secondary analyses of children 6–59 months in the ComPAS cluster randomized controlled trial |
| title_full_unstemmed | Response to malnutrition treatment in low weight-for-age children: secondary analyses of children 6–59 months in the ComPAS cluster randomized controlled trial |
| title_short | Response to malnutrition treatment in low weight-for-age children: secondary analyses of children 6–59 months in the ComPAS cluster randomized controlled trial |
| title_sort | response to malnutrition treatment in low weight for age children secondary analyses of children 6 59 months in the compas cluster randomized controlled trial |
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