Bronchial thermoplasty and biological therapy as targeted treatments for severe uncontrolled asthma
Although a small proportion of patients with asthma have severe disease, it accounts for the majority of morbidity related to the illness. Severe asthma comprises a heterogeneous group of phenotypes. Targeted treatments for these phenotypes represent a major advancement in the management of severe a...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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Elsevier
2016
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| _version_ | 1797073890222014464 |
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| author | Trivedi, A Pavord, I Castro, M |
| author_facet | Trivedi, A Pavord, I Castro, M |
| author_sort | Trivedi, A |
| collection | OXFORD |
| description | Although a small proportion of patients with asthma have severe disease, it accounts for the majority of morbidity related to the illness. Severe asthma comprises a heterogeneous group of phenotypes. Targeted treatments for these phenotypes represent a major advancement in the management of severe asthma. Omalizumab, a monoclonal antibody to IgE, improves asthma control in patients with a predominant allergic phenotype. Monoclonal antibodies targeted to interleukin 4α and interleukin 5 have shown substantial benefit in patients with the eosinophilic asthma phenotype; so too have monoclonal antibodies targeted to interleukin 13 in patients with a type 2 allergic phenotype. Bronchial thermoplasty, a new technique to reduce airway smooth muscle mass, improves symptoms and reduces exacerbations in patients with severe uncontrolled asthma and the chronic airflow obstruction phenotype. While awaiting comparative trials, we can now use a targeted approach with these phenotypes, guiding our treatment selection with the best evidence. This Review will focus on the latest developments in these new treatments and inform the clinician on how to select the appropriate patient for these treatments. |
| first_indexed | 2024-03-06T23:28:26Z |
| format | Journal article |
| id | oxford-uuid:6b35d817-828b-4edf-9512-b85237b66c11 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:28:26Z |
| publishDate | 2016 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:6b35d817-828b-4edf-9512-b85237b66c112022-03-26T19:02:18ZBronchial thermoplasty and biological therapy as targeted treatments for severe uncontrolled asthmaJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:6b35d817-828b-4edf-9512-b85237b66c11EnglishSymplectic Elements at OxfordElsevier2016Trivedi, APavord, ICastro, MAlthough a small proportion of patients with asthma have severe disease, it accounts for the majority of morbidity related to the illness. Severe asthma comprises a heterogeneous group of phenotypes. Targeted treatments for these phenotypes represent a major advancement in the management of severe asthma. Omalizumab, a monoclonal antibody to IgE, improves asthma control in patients with a predominant allergic phenotype. Monoclonal antibodies targeted to interleukin 4α and interleukin 5 have shown substantial benefit in patients with the eosinophilic asthma phenotype; so too have monoclonal antibodies targeted to interleukin 13 in patients with a type 2 allergic phenotype. Bronchial thermoplasty, a new technique to reduce airway smooth muscle mass, improves symptoms and reduces exacerbations in patients with severe uncontrolled asthma and the chronic airflow obstruction phenotype. While awaiting comparative trials, we can now use a targeted approach with these phenotypes, guiding our treatment selection with the best evidence. This Review will focus on the latest developments in these new treatments and inform the clinician on how to select the appropriate patient for these treatments. |
| spellingShingle | Trivedi, A Pavord, I Castro, M Bronchial thermoplasty and biological therapy as targeted treatments for severe uncontrolled asthma |
| title | Bronchial thermoplasty and biological therapy as targeted treatments for severe uncontrolled asthma |
| title_full | Bronchial thermoplasty and biological therapy as targeted treatments for severe uncontrolled asthma |
| title_fullStr | Bronchial thermoplasty and biological therapy as targeted treatments for severe uncontrolled asthma |
| title_full_unstemmed | Bronchial thermoplasty and biological therapy as targeted treatments for severe uncontrolled asthma |
| title_short | Bronchial thermoplasty and biological therapy as targeted treatments for severe uncontrolled asthma |
| title_sort | bronchial thermoplasty and biological therapy as targeted treatments for severe uncontrolled asthma |
| work_keys_str_mv | AT trivedia bronchialthermoplastyandbiologicaltherapyastargetedtreatmentsforsevereuncontrolledasthma AT pavordi bronchialthermoplastyandbiologicaltherapyastargetedtreatmentsforsevereuncontrolledasthma AT castrom bronchialthermoplastyandbiologicaltherapyastargetedtreatmentsforsevereuncontrolledasthma |