Large scale meta-analysis identifies new genetic risk loci for esophageal adenocarcinoma (EA) and the first EA risk locus independent of Barrett’s esophagus
<p>Esophageal adenocarcinoma (EA) is an often fatal cancer with rising incidence in the developed world. Barrett’s esophagus (BE) is a pre-cancerous metaplastic precursor of EA. We performed the first genome-wide association study (GWAS) meta-analysis for BE and EA to date, using 6,167 BE case...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Journal article |
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Elsevier
2016
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| _version_ | 1797073902208286720 |
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| author | Palles, C Tomlinson, I Chegwidden, L Gharahkhani, P MacGregor, S Vaughan, T Schumacher, J Jankowski, J Fitzgerald, R Gockel, I Buas, M Knapp, M Noethen, M Becker, J Pharaoh, P Whiteman, D |
| author_facet | Palles, C Tomlinson, I Chegwidden, L Gharahkhani, P MacGregor, S Vaughan, T Schumacher, J Jankowski, J Fitzgerald, R Gockel, I Buas, M Knapp, M Noethen, M Becker, J Pharaoh, P Whiteman, D |
| author_sort | Palles, C |
| collection | OXFORD |
| description | <p>Esophageal adenocarcinoma (EA) is an often fatal cancer with rising incidence in the developed world. Barrett’s esophagus (BE) is a pre-cancerous metaplastic precursor of EA. We performed the first genome-wide association study (GWAS) meta-analysis for BE and EA to date, using 6,167 BE cases, 4,112 EA cases, and 17,159 unscreened controls, all of European descent. We identified eight new genome-wide significant associated (P<5×10-8) risk loci for BE and/or EA within or near CFTR, MSRA, BLK, KHDRBS2, TPPP/CEP72, TMOD1, SATB2, and HTR3C/ABCC5 genes. We identified a further novel risk locus at LPA after re-weighting results using significantly enriched annotations. Bioinformatic analysis provided further support for an involvement of the identified loci in development of BE and EA.</p> |
| first_indexed | 2024-03-06T23:28:37Z |
| format | Journal article |
| id | oxford-uuid:6b429903-9518-452f-b3ea-402aa56301a3 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T23:28:37Z |
| publishDate | 2016 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:6b429903-9518-452f-b3ea-402aa56301a32022-03-26T19:02:47ZLarge scale meta-analysis identifies new genetic risk loci for esophageal adenocarcinoma (EA) and the first EA risk locus independent of Barrett’s esophagusJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:6b429903-9518-452f-b3ea-402aa56301a3Symplectic Elements at OxfordElsevier2016Palles, CTomlinson, IChegwidden, LGharahkhani, PMacGregor, SVaughan, TSchumacher, JJankowski, JFitzgerald, RGockel, IBuas, MKnapp, MNoethen, MBecker, JPharaoh, PWhiteman, D<p>Esophageal adenocarcinoma (EA) is an often fatal cancer with rising incidence in the developed world. Barrett’s esophagus (BE) is a pre-cancerous metaplastic precursor of EA. We performed the first genome-wide association study (GWAS) meta-analysis for BE and EA to date, using 6,167 BE cases, 4,112 EA cases, and 17,159 unscreened controls, all of European descent. We identified eight new genome-wide significant associated (P<5×10-8) risk loci for BE and/or EA within or near CFTR, MSRA, BLK, KHDRBS2, TPPP/CEP72, TMOD1, SATB2, and HTR3C/ABCC5 genes. We identified a further novel risk locus at LPA after re-weighting results using significantly enriched annotations. Bioinformatic analysis provided further support for an involvement of the identified loci in development of BE and EA.</p> |
| spellingShingle | Palles, C Tomlinson, I Chegwidden, L Gharahkhani, P MacGregor, S Vaughan, T Schumacher, J Jankowski, J Fitzgerald, R Gockel, I Buas, M Knapp, M Noethen, M Becker, J Pharaoh, P Whiteman, D Large scale meta-analysis identifies new genetic risk loci for esophageal adenocarcinoma (EA) and the first EA risk locus independent of Barrett’s esophagus |
| title | Large scale meta-analysis identifies new genetic risk loci for esophageal adenocarcinoma (EA) and the first EA risk locus independent of Barrett’s esophagus |
| title_full | Large scale meta-analysis identifies new genetic risk loci for esophageal adenocarcinoma (EA) and the first EA risk locus independent of Barrett’s esophagus |
| title_fullStr | Large scale meta-analysis identifies new genetic risk loci for esophageal adenocarcinoma (EA) and the first EA risk locus independent of Barrett’s esophagus |
| title_full_unstemmed | Large scale meta-analysis identifies new genetic risk loci for esophageal adenocarcinoma (EA) and the first EA risk locus independent of Barrett’s esophagus |
| title_short | Large scale meta-analysis identifies new genetic risk loci for esophageal adenocarcinoma (EA) and the first EA risk locus independent of Barrett’s esophagus |
| title_sort | large scale meta analysis identifies new genetic risk loci for esophageal adenocarcinoma ea and the first ea risk locus independent of barrett s esophagus |
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