Iridium-catalysed synthesis of C, N, N -cyclic azomethine imines enables entry to unexplored nitrogen-rich 3D chemical space

Three-dimensional nitrogen-rich bridged ring systems are of great interest in drug discovery owing to their distinctive physicochemical and structural properties. However, synthetic approaches towards N–N-bond-containing bridged heterocycles are often inefficient and require tedious synthetic strate...

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Autori principali: Almehmadi, YA, McGeehan, J, Guzman, NJ, Christensen, KE, Yamazaki, K, Dixon, DJ
Natura: Journal article
Lingua:English
Pubblicazione: Nature Research 2024