Structure of the ligand-blocked periplasmic entrance of the bacterial multidrug efflux protein TolC.

Structure of the ligand-blocked periplasmic entrance of the bacterial multidrug efflux protein TolC.

The trimeric TolC protein of Escherichia coli comprises an outer membrane beta-barrel and a contiguous alpha-helical barrel projecting across the periplasm. This provides a single 140 A long pore for multidrug efflux and protein export. We have previously reported that trivalent cations such as hexa...

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Bibliografische gegevens
Hoofdauteurs:	Higgins, M, Eswaran, J, Edwards, P, Schertler, G, Hughes, C, Koronakis, V
Formaat:	Journal article
Taal:	English
Gepubliceerd in:	2004

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