Regulation of the Drosophila bHLH-PAS protein Sima by hypoxia: functional evidence for homology with mammalian HIF-1 alpha.
Hypoxia inducible factor-1 (HIF-1) is a heterodimeric complex of two basic-helix-loop-helix proteins of the PAS family which is critical for oxygen-dependent expression of many mammalian genes. Regulation is mediated by the alpha subunit (HIF-1 alpha) and sequences from HIF-1 alpha can confer hypoxi...
Autori principali: | Bacon, N, Wappner, P, O'Rourke, J, Bartlett, S, Shilo, B, Pugh, C, Ratcliffe, P |
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Natura: | Journal article |
Lingua: | English |
Pubblicazione: |
1998
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