Regulation of the Drosophila bHLH-PAS protein Sima by hypoxia: functional evidence for homology with mammalian HIF-1 alpha.

Regulation of the Drosophila bHLH-PAS protein Sima by hypoxia: functional evidence for homology with mammalian HIF-1 alpha.

Hypoxia inducible factor-1 (HIF-1) is a heterodimeric complex of two basic-helix-loop-helix proteins of the PAS family which is critical for oxygen-dependent expression of many mammalian genes. Regulation is mediated by the alpha subunit (HIF-1 alpha) and sequences from HIF-1 alpha can confer hypoxi...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Bacon, N, Wappner, P, O'Rourke, J, Bartlett, S, Shilo, B, Pugh, C, Ratcliffe, P
Format: Journal article
Sprache:English
Veröffentlicht: 1998

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