Virtual fragment screening identification of a novel Quinoline-5,8-dicarboxylic acid derivative as selective JMJD3 inhibitor.
The quinoline-5,8 dicarboxylic acid scaffold has been identified by fragment-based approach as new potential lead compound for the development of JMJD3 inhibitors. Among them, compound 3 shows low micromolar inhibitory activity against JMJD3. The experimental evaluation of inhibition activity vs. re...
Full description
Bibliographic Details
| Main Authors: |
Giordano, A,
Del Gaudio, F,
Johansson, C,
Riccio, R,
Oppermann, U,
Di Micco, S |
|---|
| Format: | Journal article
|
|---|
| Language: | English |
|---|
| Published: |
Wiley
2018
|
|---|