Memory T cell inflation: Understanding cause and effect
Typically, during viral infections, T cells encounter antigen, undergo proliferative expansion and ultimately contract into a pool of memory cells. However, after infection with cytomegalovirus, a ubiquitous β-herpesvirus, T cell populations specific for certain epitopes do not contract but instead...
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| Fformat: | Journal article |
| Iaith: | English |
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2012
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| _version_ | 1826277482438852608 |
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| author | O'Hara, G Welten, S Klenerman, P Arens, R |
| author_facet | O'Hara, G Welten, S Klenerman, P Arens, R |
| author_sort | O'Hara, G |
| collection | OXFORD |
| description | Typically, during viral infections, T cells encounter antigen, undergo proliferative expansion and ultimately contract into a pool of memory cells. However, after infection with cytomegalovirus, a ubiquitous β-herpesvirus, T cell populations specific for certain epitopes do not contract but instead are maintained and/or accumulate at high frequencies with a characteristic effector-memory phenotype. This feature has also been noted after other infections, for example, by parvoviruses. We discuss this so-called memory T cell inflation and the factors involved in this phenomenon. Also, we consider the potential therapeutic use of memory T cell inflation as a vaccine strategy and the associated implications for immune senescence. © 2011 Elsevier Ltd. |
| first_indexed | 2024-03-06T23:29:34Z |
| format | Journal article |
| id | oxford-uuid:6b8cc367-0c2c-417c-8ae7-fb6a570fda26 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:29:34Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:6b8cc367-0c2c-417c-8ae7-fb6a570fda262022-03-26T19:04:50ZMemory T cell inflation: Understanding cause and effectJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:6b8cc367-0c2c-417c-8ae7-fb6a570fda26EnglishSymplectic Elements at Oxford2012O'Hara, GWelten, SKlenerman, PArens, RTypically, during viral infections, T cells encounter antigen, undergo proliferative expansion and ultimately contract into a pool of memory cells. However, after infection with cytomegalovirus, a ubiquitous β-herpesvirus, T cell populations specific for certain epitopes do not contract but instead are maintained and/or accumulate at high frequencies with a characteristic effector-memory phenotype. This feature has also been noted after other infections, for example, by parvoviruses. We discuss this so-called memory T cell inflation and the factors involved in this phenomenon. Also, we consider the potential therapeutic use of memory T cell inflation as a vaccine strategy and the associated implications for immune senescence. © 2011 Elsevier Ltd. |
| spellingShingle | O'Hara, G Welten, S Klenerman, P Arens, R Memory T cell inflation: Understanding cause and effect |
| title | Memory T cell inflation: Understanding cause and effect |
| title_full | Memory T cell inflation: Understanding cause and effect |
| title_fullStr | Memory T cell inflation: Understanding cause and effect |
| title_full_unstemmed | Memory T cell inflation: Understanding cause and effect |
| title_short | Memory T cell inflation: Understanding cause and effect |
| title_sort | memory t cell inflation understanding cause and effect |
| work_keys_str_mv | AT oharag memorytcellinflationunderstandingcauseandeffect AT weltens memorytcellinflationunderstandingcauseandeffect AT klenermanp memorytcellinflationunderstandingcauseandeffect AT arensr memorytcellinflationunderstandingcauseandeffect |