Residue-selective protein C-formylation via sequential difluoroalkylation-hydrolysis

The carbonyl group is now a widely useful, nonproteinogenic functional group in chemical biology, yet methods for its generation in proteins have relied upon either cotranslational incorporation of unnatural amino acids bearing carbonyls or oxidative conversion (chemical or enzymatic) of existing na...

Полное описание

Библиографические подробности
Главные авторы: Imiołek, M, Isenegger, PG, Ng, W-L, Khan, A, Gouverneur, V, Davis, BG
Формат: Journal article
Язык:English
Опубликовано: American Chemical Society 2021