The topology of transcription by immobilized polymerases.
Current models for RNA synthesis involve an RNA polymerase that tracks along a static template. However, research on chromatin loops suggests that the template slides past a polymerase immobilized in a large transcription factory. The evidence for immobilized polymerases is reviewed, and a model for...
| Main Authors: | , , , , |
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| Format: | Conference item |
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1996
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| _version_ | 1826277501098262528 |
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| author | Iborra, F Pombo, A McManus, J Jackson, D Cook, P |
| author_facet | Iborra, F Pombo, A McManus, J Jackson, D Cook, P |
| author_sort | Iborra, F |
| collection | OXFORD |
| description | Current models for RNA synthesis involve an RNA polymerase that tracks along a static template. However, research on chromatin loops suggests that the template slides past a polymerase immobilized in a large transcription factory. The evidence for immobilized polymerases is reviewed, and a model for transcription by such fixed enzymes is presented. According to the model, gene activation would involve reducing gene-factory distance and increasing the affinity of a promoter for a factory. Locus controlling regions and enhancers would attach to a factory and increase the chances that a promoter could bind to a polymerase; after transcriptional termination, the gene would detach from the factory. As some RNA processing occurs cotranscriptionally, processing sites are also likely to be associated with the factory. |
| first_indexed | 2024-03-06T23:29:50Z |
| format | Conference item |
| id | oxford-uuid:6ba79cc7-846c-4923-ac41-974848168931 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T23:29:50Z |
| publishDate | 1996 |
| record_format | dspace |
| spelling | oxford-uuid:6ba79cc7-846c-4923-ac41-9748481689312022-03-26T19:05:28ZThe topology of transcription by immobilized polymerases.Conference itemhttp://purl.org/coar/resource_type/c_5794uuid:6ba79cc7-846c-4923-ac41-974848168931Symplectic Elements at Oxford1996Iborra, FPombo, AMcManus, JJackson, DCook, PCurrent models for RNA synthesis involve an RNA polymerase that tracks along a static template. However, research on chromatin loops suggests that the template slides past a polymerase immobilized in a large transcription factory. The evidence for immobilized polymerases is reviewed, and a model for transcription by such fixed enzymes is presented. According to the model, gene activation would involve reducing gene-factory distance and increasing the affinity of a promoter for a factory. Locus controlling regions and enhancers would attach to a factory and increase the chances that a promoter could bind to a polymerase; after transcriptional termination, the gene would detach from the factory. As some RNA processing occurs cotranscriptionally, processing sites are also likely to be associated with the factory. |
| spellingShingle | Iborra, F Pombo, A McManus, J Jackson, D Cook, P The topology of transcription by immobilized polymerases. |
| title | The topology of transcription by immobilized polymerases. |
| title_full | The topology of transcription by immobilized polymerases. |
| title_fullStr | The topology of transcription by immobilized polymerases. |
| title_full_unstemmed | The topology of transcription by immobilized polymerases. |
| title_short | The topology of transcription by immobilized polymerases. |
| title_sort | topology of transcription by immobilized polymerases |
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