Structure and function of the human Gly1619Arg polymorphism of M6P/IGF2R domain 11 implicated in IGF2 dependent growth.

Structure and function of the human Gly1619Arg polymorphism of M6P/IGF2R domain 11 implicated in IGF2 dependent growth.

The mannose 6-phosphate/IGF 2 receptor (IGF2R) is comprised of 15 extra-cellular domains that bind IGF2 and mannose 6-phosphate ligands. IGF2R transports ligands from the Golgi to the pre-lysosomal compartment and thereafter to and from the cell surface. IGF2R regulates growth, placental development...

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Bibliographic Details
Main Authors:	Rezgui, D, Williams, C, Savage, SA, Prince, SN, Zaccheo, O, Jones, E, Crump, M, Hassan, A
Format:	Journal article
Language:	English
Published:	2009

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