Biomimetic synthesis, antibacterial activity and structure-activity properties of the pyroglutamate core of oxazolomycin
Biomimetic intramolecular aldol reactions on oxazolidine templates derived from serine may be used to generate densely functionalised pyroglutamates, which are simpler mimics of the right hand side of oxazolomycin. Some of the compounds from this sequence exhibit in vivo activity against S. aureus a...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
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Royal Society of Chemistry
2012
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| _version_ | 1797074035009388544 |
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| author | Angelov, P Chau, Y Fryer, P Moloney, M Thompson, A Trippier, P |
| author_facet | Angelov, P Chau, Y Fryer, P Moloney, M Thompson, A Trippier, P |
| author_sort | Angelov, P |
| collection | OXFORD |
| description | Biomimetic intramolecular aldol reactions on oxazolidine templates derived from serine may be used to generate densely functionalised pyroglutamates, which are simpler mimics of the right hand side of oxazolomycin. Some of the compounds from this sequence exhibit in vivo activity against S. aureus and E. coli, suggesting that pyroglutamate scaffolds may be useful templates for the development of novel antibacterials, and cheminformatic analysis has been used to provide some structure-activity data. |
| first_indexed | 2024-03-06T23:30:32Z |
| format | Journal article |
| id | oxford-uuid:6bdf2e52-9fa3-409c-929b-9c352c93baa2 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:30:32Z |
| publishDate | 2012 |
| publisher | Royal Society of Chemistry |
| record_format | dspace |
| spelling | oxford-uuid:6bdf2e52-9fa3-409c-929b-9c352c93baa22022-03-26T19:07:01ZBiomimetic synthesis, antibacterial activity and structure-activity properties of the pyroglutamate core of oxazolomycinJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:6bdf2e52-9fa3-409c-929b-9c352c93baa2EnglishSymplectic Elements at OxfordRoyal Society of Chemistry2012Angelov, PChau, YFryer, PMoloney, MThompson, ATrippier, PBiomimetic intramolecular aldol reactions on oxazolidine templates derived from serine may be used to generate densely functionalised pyroglutamates, which are simpler mimics of the right hand side of oxazolomycin. Some of the compounds from this sequence exhibit in vivo activity against S. aureus and E. coli, suggesting that pyroglutamate scaffolds may be useful templates for the development of novel antibacterials, and cheminformatic analysis has been used to provide some structure-activity data. |
| spellingShingle | Angelov, P Chau, Y Fryer, P Moloney, M Thompson, A Trippier, P Biomimetic synthesis, antibacterial activity and structure-activity properties of the pyroglutamate core of oxazolomycin |
| title | Biomimetic synthesis, antibacterial activity and structure-activity properties of the pyroglutamate core of oxazolomycin |
| title_full | Biomimetic synthesis, antibacterial activity and structure-activity properties of the pyroglutamate core of oxazolomycin |
| title_fullStr | Biomimetic synthesis, antibacterial activity and structure-activity properties of the pyroglutamate core of oxazolomycin |
| title_full_unstemmed | Biomimetic synthesis, antibacterial activity and structure-activity properties of the pyroglutamate core of oxazolomycin |
| title_short | Biomimetic synthesis, antibacterial activity and structure-activity properties of the pyroglutamate core of oxazolomycin |
| title_sort | biomimetic synthesis antibacterial activity and structure activity properties of the pyroglutamate core of oxazolomycin |
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