Fitness costs and the rapid spread of kelch13-C580Y substitutions conferring artemisinin resistance

Fitness costs and the rapid spread of kelch13-C580Y substitutions conferring artemisinin resistance

Fitness costs are key determinants of whether drug resistance alleles establish and how fast they spread within populations. More than 125 different kelch13 alleles, each containing a different amino acid substitution, have arisen in SE Asian malaria parasite (Plasmodium falciparum) populations unde...

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Bibliographic Details
Main Authors:	Nair, S, Li, X, Arya, G, McDew-white, M, Ferrari, M, Nosten, F, Anderson, T
Format:	Journal article
Language:	English
Published:	American Society for Microbiology 2018

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