Preeclampsia: risk factors, diagnosis, management, and the cardiovascular impact on the offspring
Hypertensive disorders of pregnancy affect up to 10% of pregnancies worldwide, which includes the 3%-5% of all pregnancies complicated by preeclampsia. Preeclampsia is defined as new onset hypertension after 20 weeks' gestation with evidence of maternal organ or uteroplacental dysfunction or pr...
| Những tác giả chính: | , , , , |
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| Định dạng: | Journal article |
| Ngôn ngữ: | English |
| Được phát hành: |
MDPI
2019
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| _version_ | 1826277627923529728 |
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| author | Fox, R Kitt, J Leeson, P Aye, C Lewandowski, A |
| author_facet | Fox, R Kitt, J Leeson, P Aye, C Lewandowski, A |
| author_sort | Fox, R |
| collection | OXFORD |
| description | Hypertensive disorders of pregnancy affect up to 10% of pregnancies worldwide, which includes the 3%-5% of all pregnancies complicated by preeclampsia. Preeclampsia is defined as new onset hypertension after 20 weeks' gestation with evidence of maternal organ or uteroplacental dysfunction or proteinuria. Despite its prevalence, the risk factors that have been identified lack accuracy in predicting its onset and preventative therapies only moderately reduce a woman's risk of preeclampsia. Preeclampsia is a major cause of maternal morbidity and is associated with adverse foetal outcomes including intra-uterine growth restriction, preterm birth, placental abruption, foetal distress, and foetal death in utero. At present, national guidelines for foetal surveillance in preeclamptic pregnancies are inconsistent, due to a lack of evidence detailing the most appropriate assessment modalities as well as the timing and frequency at which assessments should be conducted. Current management of the foetus in preeclampsia involves timely delivery and prevention of adverse effects of prematurity with antenatal corticosteroids and/or magnesium sulphate depending on gestation. Alongside the risks to the foetus during pregnancy, there is also growing evidence that preeclampsia has long-term adverse effects on the offspring. In particular, preeclampsia has been associated with cardiovascular sequelae in the offspring including hypertension and altered vascular function. |
| first_indexed | 2024-03-06T23:31:45Z |
| format | Journal article |
| id | oxford-uuid:6c464433-aedd-4f67-b262-a6fb25c37a15 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:31:45Z |
| publishDate | 2019 |
| publisher | MDPI |
| record_format | dspace |
| spelling | oxford-uuid:6c464433-aedd-4f67-b262-a6fb25c37a152022-03-26T19:09:44ZPreeclampsia: risk factors, diagnosis, management, and the cardiovascular impact on the offspringJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:6c464433-aedd-4f67-b262-a6fb25c37a15EnglishSymplectic Elements at OxfordMDPI2019Fox, RKitt, JLeeson, PAye, CLewandowski, AHypertensive disorders of pregnancy affect up to 10% of pregnancies worldwide, which includes the 3%-5% of all pregnancies complicated by preeclampsia. Preeclampsia is defined as new onset hypertension after 20 weeks' gestation with evidence of maternal organ or uteroplacental dysfunction or proteinuria. Despite its prevalence, the risk factors that have been identified lack accuracy in predicting its onset and preventative therapies only moderately reduce a woman's risk of preeclampsia. Preeclampsia is a major cause of maternal morbidity and is associated with adverse foetal outcomes including intra-uterine growth restriction, preterm birth, placental abruption, foetal distress, and foetal death in utero. At present, national guidelines for foetal surveillance in preeclamptic pregnancies are inconsistent, due to a lack of evidence detailing the most appropriate assessment modalities as well as the timing and frequency at which assessments should be conducted. Current management of the foetus in preeclampsia involves timely delivery and prevention of adverse effects of prematurity with antenatal corticosteroids and/or magnesium sulphate depending on gestation. Alongside the risks to the foetus during pregnancy, there is also growing evidence that preeclampsia has long-term adverse effects on the offspring. In particular, preeclampsia has been associated with cardiovascular sequelae in the offspring including hypertension and altered vascular function. |
| spellingShingle | Fox, R Kitt, J Leeson, P Aye, C Lewandowski, A Preeclampsia: risk factors, diagnosis, management, and the cardiovascular impact on the offspring |
| title | Preeclampsia: risk factors, diagnosis, management, and the cardiovascular impact on the offspring |
| title_full | Preeclampsia: risk factors, diagnosis, management, and the cardiovascular impact on the offspring |
| title_fullStr | Preeclampsia: risk factors, diagnosis, management, and the cardiovascular impact on the offspring |
| title_full_unstemmed | Preeclampsia: risk factors, diagnosis, management, and the cardiovascular impact on the offspring |
| title_short | Preeclampsia: risk factors, diagnosis, management, and the cardiovascular impact on the offspring |
| title_sort | preeclampsia risk factors diagnosis management and the cardiovascular impact on the offspring |
| work_keys_str_mv | AT foxr preeclampsiariskfactorsdiagnosismanagementandthecardiovascularimpactontheoffspring AT kittj preeclampsiariskfactorsdiagnosismanagementandthecardiovascularimpactontheoffspring AT leesonp preeclampsiariskfactorsdiagnosismanagementandthecardiovascularimpactontheoffspring AT ayec preeclampsiariskfactorsdiagnosismanagementandthecardiovascularimpactontheoffspring AT lewandowskia preeclampsiariskfactorsdiagnosismanagementandthecardiovascularimpactontheoffspring |