Relating functional changes during hand movement to clinical parameters in patients with multiple sclerosis in a multi-centre fMRI study.
We performed a prospective multi-centre study using functional magnetic resonance imaging (fMRI) to better characterize the relationships between clinical expression and brain function in patients with multiple sclerosis (MS) at eight European sites (56 MS patients and 60 age-matched, healthy contro...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2008
|
| _version_ | 1797074145919369216 |
|---|---|
| author | Wegner, C Filippi, M Korteweg, T Beckmann, C Ciccarelli, O De Stefano, N Enzinger, C Fazekas, F Agosta, F Gass, A Hirsch, J Johansen-Berg, H Kappos, L Barkhof, F Polman, C Mancini, L Manfredonia, F Marino, S Miller, D Montalban, X Palace, J Rocca, M Ropele, S Rovira, A Smith, S |
| author_facet | Wegner, C Filippi, M Korteweg, T Beckmann, C Ciccarelli, O De Stefano, N Enzinger, C Fazekas, F Agosta, F Gass, A Hirsch, J Johansen-Berg, H Kappos, L Barkhof, F Polman, C Mancini, L Manfredonia, F Marino, S Miller, D Montalban, X Palace, J Rocca, M Ropele, S Rovira, A Smith, S |
| author_sort | Wegner, C |
| collection | OXFORD |
| description | We performed a prospective multi-centre study using functional magnetic resonance imaging (fMRI) to better characterize the relationships between clinical expression and brain function in patients with multiple sclerosis (MS) at eight European sites (56 MS patients and 60 age-matched, healthy controls). Patients showed greater task-related activation bilaterally in brain regions including the pre- and post-central, inferior and superior frontal, cingulate and superior temporal gyri and insula (P < 0.05, all statistics corrected for multiple comparisons). Both patients and healthy controls showed greater brain activation with increasing age in the ipsilateral pre-central and inferior frontal gyri (P < 0.05). Patients, but not controls, showed greater brain activation in the anterior cingulate gyrus and the bilateral ventral striatum (P < 0.05) with less hand dexterity. An interaction between functional activation changes in MS and age was found. This large fMRI study over a broadly selected MS patient population confirms that movement for patients demands significantly greater cognitive 'resource allocation' and suggests age-related differences in brain responses to the disease. These observations add to evidence that brain functional responses (including potentially adaptive brain plasticity) contribute to modulation of clinical expression of MS pathology and demonstrate the feasibility of a multi-site functional MRI study of MS. |
| first_indexed | 2024-03-06T23:32:08Z |
| format | Journal article |
| id | oxford-uuid:6c652d8b-391d-4fc4-ae20-0e3bb34a1dca |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:32:08Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:6c652d8b-391d-4fc4-ae20-0e3bb34a1dca2022-03-26T19:10:38ZRelating functional changes during hand movement to clinical parameters in patients with multiple sclerosis in a multi-centre fMRI study.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:6c652d8b-391d-4fc4-ae20-0e3bb34a1dcaEnglishSymplectic Elements at Oxford2008Wegner, CFilippi, MKorteweg, TBeckmann, CCiccarelli, ODe Stefano, NEnzinger, CFazekas, FAgosta, FGass, AHirsch, JJohansen-Berg, HKappos, LBarkhof, FPolman, CMancini, LManfredonia, FMarino, SMiller, DMontalban, XPalace, JRocca, MRopele, SRovira, ASmith, SWe performed a prospective multi-centre study using functional magnetic resonance imaging (fMRI) to better characterize the relationships between clinical expression and brain function in patients with multiple sclerosis (MS) at eight European sites (56 MS patients and 60 age-matched, healthy controls). Patients showed greater task-related activation bilaterally in brain regions including the pre- and post-central, inferior and superior frontal, cingulate and superior temporal gyri and insula (P < 0.05, all statistics corrected for multiple comparisons). Both patients and healthy controls showed greater brain activation with increasing age in the ipsilateral pre-central and inferior frontal gyri (P < 0.05). Patients, but not controls, showed greater brain activation in the anterior cingulate gyrus and the bilateral ventral striatum (P < 0.05) with less hand dexterity. An interaction between functional activation changes in MS and age was found. This large fMRI study over a broadly selected MS patient population confirms that movement for patients demands significantly greater cognitive 'resource allocation' and suggests age-related differences in brain responses to the disease. These observations add to evidence that brain functional responses (including potentially adaptive brain plasticity) contribute to modulation of clinical expression of MS pathology and demonstrate the feasibility of a multi-site functional MRI study of MS. |
| spellingShingle | Wegner, C Filippi, M Korteweg, T Beckmann, C Ciccarelli, O De Stefano, N Enzinger, C Fazekas, F Agosta, F Gass, A Hirsch, J Johansen-Berg, H Kappos, L Barkhof, F Polman, C Mancini, L Manfredonia, F Marino, S Miller, D Montalban, X Palace, J Rocca, M Ropele, S Rovira, A Smith, S Relating functional changes during hand movement to clinical parameters in patients with multiple sclerosis in a multi-centre fMRI study. |
| title | Relating functional changes during hand movement to clinical parameters in patients with multiple sclerosis in a multi-centre fMRI study. |
| title_full | Relating functional changes during hand movement to clinical parameters in patients with multiple sclerosis in a multi-centre fMRI study. |
| title_fullStr | Relating functional changes during hand movement to clinical parameters in patients with multiple sclerosis in a multi-centre fMRI study. |
| title_full_unstemmed | Relating functional changes during hand movement to clinical parameters in patients with multiple sclerosis in a multi-centre fMRI study. |
| title_short | Relating functional changes during hand movement to clinical parameters in patients with multiple sclerosis in a multi-centre fMRI study. |
| title_sort | relating functional changes during hand movement to clinical parameters in patients with multiple sclerosis in a multi centre fmri study |
| work_keys_str_mv | AT wegnerc relatingfunctionalchangesduringhandmovementtoclinicalparametersinpatientswithmultiplesclerosisinamulticentrefmristudy AT filippim relatingfunctionalchangesduringhandmovementtoclinicalparametersinpatientswithmultiplesclerosisinamulticentrefmristudy AT kortewegt relatingfunctionalchangesduringhandmovementtoclinicalparametersinpatientswithmultiplesclerosisinamulticentrefmristudy AT beckmannc relatingfunctionalchangesduringhandmovementtoclinicalparametersinpatientswithmultiplesclerosisinamulticentrefmristudy AT ciccarellio relatingfunctionalchangesduringhandmovementtoclinicalparametersinpatientswithmultiplesclerosisinamulticentrefmristudy AT destefanon relatingfunctionalchangesduringhandmovementtoclinicalparametersinpatientswithmultiplesclerosisinamulticentrefmristudy AT enzingerc relatingfunctionalchangesduringhandmovementtoclinicalparametersinpatientswithmultiplesclerosisinamulticentrefmristudy AT fazekasf relatingfunctionalchangesduringhandmovementtoclinicalparametersinpatientswithmultiplesclerosisinamulticentrefmristudy AT agostaf relatingfunctionalchangesduringhandmovementtoclinicalparametersinpatientswithmultiplesclerosisinamulticentrefmristudy AT gassa relatingfunctionalchangesduringhandmovementtoclinicalparametersinpatientswithmultiplesclerosisinamulticentrefmristudy AT hirschj relatingfunctionalchangesduringhandmovementtoclinicalparametersinpatientswithmultiplesclerosisinamulticentrefmristudy AT johansenbergh relatingfunctionalchangesduringhandmovementtoclinicalparametersinpatientswithmultiplesclerosisinamulticentrefmristudy AT kapposl relatingfunctionalchangesduringhandmovementtoclinicalparametersinpatientswithmultiplesclerosisinamulticentrefmristudy AT barkhoff relatingfunctionalchangesduringhandmovementtoclinicalparametersinpatientswithmultiplesclerosisinamulticentrefmristudy AT polmanc relatingfunctionalchangesduringhandmovementtoclinicalparametersinpatientswithmultiplesclerosisinamulticentrefmristudy AT mancinil relatingfunctionalchangesduringhandmovementtoclinicalparametersinpatientswithmultiplesclerosisinamulticentrefmristudy AT manfredoniaf relatingfunctionalchangesduringhandmovementtoclinicalparametersinpatientswithmultiplesclerosisinamulticentrefmristudy AT marinos relatingfunctionalchangesduringhandmovementtoclinicalparametersinpatientswithmultiplesclerosisinamulticentrefmristudy AT millerd relatingfunctionalchangesduringhandmovementtoclinicalparametersinpatientswithmultiplesclerosisinamulticentrefmristudy AT montalbanx relatingfunctionalchangesduringhandmovementtoclinicalparametersinpatientswithmultiplesclerosisinamulticentrefmristudy AT palacej relatingfunctionalchangesduringhandmovementtoclinicalparametersinpatientswithmultiplesclerosisinamulticentrefmristudy AT roccam relatingfunctionalchangesduringhandmovementtoclinicalparametersinpatientswithmultiplesclerosisinamulticentrefmristudy AT ropeles relatingfunctionalchangesduringhandmovementtoclinicalparametersinpatientswithmultiplesclerosisinamulticentrefmristudy AT roviraa relatingfunctionalchangesduringhandmovementtoclinicalparametersinpatientswithmultiplesclerosisinamulticentrefmristudy AT smiths relatingfunctionalchangesduringhandmovementtoclinicalparametersinpatientswithmultiplesclerosisinamulticentrefmristudy |