Qualitative mapping of cerebral blood flow and functional localization with echo-planar MR imaging and signal targeting with alternating radio frequency.
PURPOSE: To create qualitative maps of cerebral blood flow (CBF) with the EPISTAR (echo-planar imaging and signal targeting with alternating radio frequency) technique. MATERIALS AND METHODS: The EPISTAR technique was performed in a pig model of hypercapnia and then tested in 26 volunteers by using...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1994
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| _version_ | 1797074149193023488 |
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| author | Edelman, R Siewert, B Darby, D Thangaraj, V Nobre, A Mesulam, M Warach, S |
| author_facet | Edelman, R Siewert, B Darby, D Thangaraj, V Nobre, A Mesulam, M Warach, S |
| author_sort | Edelman, R |
| collection | OXFORD |
| description | PURPOSE: To create qualitative maps of cerebral blood flow (CBF) with the EPISTAR (echo-planar imaging and signal targeting with alternating radio frequency) technique. MATERIALS AND METHODS: The EPISTAR technique was performed in a pig model of hypercapnia and then tested in 26 volunteers by using various paradigms for cortical activation. Echo-planar images were acquired with and without use of a radio-frequency inversion pulse applied to inflowing arterial spins. A qualitative map of CBF was then created by subtracting the image obtained without the radio-frequency pulse from that obtained with the radio-frequency pulse. RESULTS: Progressively more distal portions of the tagged vessels were seen as the inflow time was lengthened until cortical enhancement was seen for inflow times of approximately 1 second or longer. Signal intensity increases from rest to sensorimotor activation ranged from 13% to 193%. CBF changes in the motor strip, primary visual cortex, and the motor area for eye movements were well localized to the cortical gray matter ribbon. CONCLUSION: The EPISTAR technique is a rapid, noninvasive means for creating qualitative maps of CBF. |
| first_indexed | 2024-03-06T23:32:11Z |
| format | Journal article |
| id | oxford-uuid:6c69e8e0-2127-42a6-9c0c-a97c3424f985 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:32:11Z |
| publishDate | 1994 |
| record_format | dspace |
| spelling | oxford-uuid:6c69e8e0-2127-42a6-9c0c-a97c3424f9852022-03-26T19:10:43ZQualitative mapping of cerebral blood flow and functional localization with echo-planar MR imaging and signal targeting with alternating radio frequency.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:6c69e8e0-2127-42a6-9c0c-a97c3424f985EnglishSymplectic Elements at Oxford1994Edelman, RSiewert, BDarby, DThangaraj, VNobre, AMesulam, MWarach, SPURPOSE: To create qualitative maps of cerebral blood flow (CBF) with the EPISTAR (echo-planar imaging and signal targeting with alternating radio frequency) technique. MATERIALS AND METHODS: The EPISTAR technique was performed in a pig model of hypercapnia and then tested in 26 volunteers by using various paradigms for cortical activation. Echo-planar images were acquired with and without use of a radio-frequency inversion pulse applied to inflowing arterial spins. A qualitative map of CBF was then created by subtracting the image obtained without the radio-frequency pulse from that obtained with the radio-frequency pulse. RESULTS: Progressively more distal portions of the tagged vessels were seen as the inflow time was lengthened until cortical enhancement was seen for inflow times of approximately 1 second or longer. Signal intensity increases from rest to sensorimotor activation ranged from 13% to 193%. CBF changes in the motor strip, primary visual cortex, and the motor area for eye movements were well localized to the cortical gray matter ribbon. CONCLUSION: The EPISTAR technique is a rapid, noninvasive means for creating qualitative maps of CBF. |
| spellingShingle | Edelman, R Siewert, B Darby, D Thangaraj, V Nobre, A Mesulam, M Warach, S Qualitative mapping of cerebral blood flow and functional localization with echo-planar MR imaging and signal targeting with alternating radio frequency. |
| title | Qualitative mapping of cerebral blood flow and functional localization with echo-planar MR imaging and signal targeting with alternating radio frequency. |
| title_full | Qualitative mapping of cerebral blood flow and functional localization with echo-planar MR imaging and signal targeting with alternating radio frequency. |
| title_fullStr | Qualitative mapping of cerebral blood flow and functional localization with echo-planar MR imaging and signal targeting with alternating radio frequency. |
| title_full_unstemmed | Qualitative mapping of cerebral blood flow and functional localization with echo-planar MR imaging and signal targeting with alternating radio frequency. |
| title_short | Qualitative mapping of cerebral blood flow and functional localization with echo-planar MR imaging and signal targeting with alternating radio frequency. |
| title_sort | qualitative mapping of cerebral blood flow and functional localization with echo planar mr imaging and signal targeting with alternating radio frequency |
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