Role for the obesity-related FTO gene in the cellular sensing of amino acids.
SNPs in the first intron of FTO (fat mass and obesity associated) are strongly associated with human obesity. While it is not yet formally established that this effect is mediated through the actions of the FTO protein itself, loss of function mutations in FTO or its murine homologue Fto result in s...
Hoofdauteurs: | Gulati, P, Cheung, M, Antrobus, R, Church, C, Harding, H, Tung, Y, Rimmington, D, Ma, M, Ron, D, Lehner, P, Ashcroft, F, Cox, R, Coll, A, O'Rahilly, S, Yeo, G |
---|---|
Formaat: | Journal article |
Taal: | English |
Gepubliceerd in: |
2013
|
Gelijkaardige items
-
Adult onset global loss of the FTO gene alters body composition and metabolism in the mouse
door: McMurray, F, et al.
Gepubliceerd in: (2013) -
FTO is necessary for the induction of leptin resistance by high-fat feeding
door: Y.C. Loraine Tung, et al.
Gepubliceerd in: (2015-04-01) -
Hypothalamic-specific manipulation of Fto, the ortholog of the human obesity gene FTO, affects food intake in rats.
door: Yi-Chun Loraine Tung, et al.
Gepubliceerd in: (2010-01-01) -
Adult onset global loss of the fto gene alters body composition and metabolism in the mouse.
door: Fiona McMurray, et al.
Gepubliceerd in: (2013-01-01) -
The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase.
door: Gerken, T, et al.
Gepubliceerd in: (2007)