Impact of Spin in the Abstracts of Articles Reporting Results of Randomized Controlled Trials in the Field of Cancer: The SPIIN Randomized Controlled Trial.
PURPOSE: We aimed to assess the impact of spin (ie, reporting to convince readers that the beneficial effect of the experimental treatment is greater than shown by the results) on the interpretation of results of abstracts of randomized controlled trials (RCTs) in the field of cancer. METHODS: We pe...
| Glavni autori: | , , , , , |
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| Format: | Journal article |
| Jezik: | English |
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American Society of Clinical Oncology
2014
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| _version_ | 1826277678415609856 |
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| author | Boutron, I Altman, D Hopewell, S Vera-Badillo, F Tannock, I Ravaud, P |
| author_facet | Boutron, I Altman, D Hopewell, S Vera-Badillo, F Tannock, I Ravaud, P |
| author_sort | Boutron, I |
| collection | OXFORD |
| description | PURPOSE: We aimed to assess the impact of spin (ie, reporting to convince readers that the beneficial effect of the experimental treatment is greater than shown by the results) on the interpretation of results of abstracts of randomized controlled trials (RCTs) in the field of cancer. METHODS: We performed a two-arm, parallel-group RCT. We selected a sample of published RCTs with statistically nonsignificant primary outcome and with spin in the abstract conclusion. Two versions of these abstracts were used-the original with spin and a rewritten version without spin. Participants were clinician corresponding authors of articles reporting RCTs, investigators of trials, and reviewers of French national grants. The primary outcome was clinicians' interpretation of the beneficial effect of the experimental treatment (0 to 10 scale). Participants were blinded to study hypothesis. RESULTS: Three hundred clinicians were randomly assigned using a Web-based system; 150 clinicians assessed an abstract with spin and 150 assessed an abstract without spin. For abstracts with spin, the experimental treatment was rated as being more beneficial (mean difference, 0.71; 95% CI, 0.07 to 1.35; P = .030), the trial was rated as being less rigorous (mean difference, -0.59; 95% CI, -1.13 to 0.05; P = .034), and clinicians were more interested in reading the full-text article (mean difference, 0.77; 95% CI, 0.08 to 1.47; P = .029). There was no statistically significant difference in the clinicians' rating of the importance of the study or the need to run another trial. CONCLUSION: Spin in abstracts can have an impact on clinicians' interpretation of the trial results. |
| first_indexed | 2024-03-06T23:32:32Z |
| format | Journal article |
| id | oxford-uuid:6c8d7140-1f19-45d7-b3e6-7c8841deb70c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:32:32Z |
| publishDate | 2014 |
| publisher | American Society of Clinical Oncology |
| record_format | dspace |
| spelling | oxford-uuid:6c8d7140-1f19-45d7-b3e6-7c8841deb70c2022-03-26T19:11:41ZImpact of Spin in the Abstracts of Articles Reporting Results of Randomized Controlled Trials in the Field of Cancer: The SPIIN Randomized Controlled Trial.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:6c8d7140-1f19-45d7-b3e6-7c8841deb70cEnglishSymplectic Elements at OxfordAmerican Society of Clinical Oncology2014Boutron, IAltman, DHopewell, SVera-Badillo, FTannock, IRavaud, PPURPOSE: We aimed to assess the impact of spin (ie, reporting to convince readers that the beneficial effect of the experimental treatment is greater than shown by the results) on the interpretation of results of abstracts of randomized controlled trials (RCTs) in the field of cancer. METHODS: We performed a two-arm, parallel-group RCT. We selected a sample of published RCTs with statistically nonsignificant primary outcome and with spin in the abstract conclusion. Two versions of these abstracts were used-the original with spin and a rewritten version without spin. Participants were clinician corresponding authors of articles reporting RCTs, investigators of trials, and reviewers of French national grants. The primary outcome was clinicians' interpretation of the beneficial effect of the experimental treatment (0 to 10 scale). Participants were blinded to study hypothesis. RESULTS: Three hundred clinicians were randomly assigned using a Web-based system; 150 clinicians assessed an abstract with spin and 150 assessed an abstract without spin. For abstracts with spin, the experimental treatment was rated as being more beneficial (mean difference, 0.71; 95% CI, 0.07 to 1.35; P = .030), the trial was rated as being less rigorous (mean difference, -0.59; 95% CI, -1.13 to 0.05; P = .034), and clinicians were more interested in reading the full-text article (mean difference, 0.77; 95% CI, 0.08 to 1.47; P = .029). There was no statistically significant difference in the clinicians' rating of the importance of the study or the need to run another trial. CONCLUSION: Spin in abstracts can have an impact on clinicians' interpretation of the trial results. |
| spellingShingle | Boutron, I Altman, D Hopewell, S Vera-Badillo, F Tannock, I Ravaud, P Impact of Spin in the Abstracts of Articles Reporting Results of Randomized Controlled Trials in the Field of Cancer: The SPIIN Randomized Controlled Trial. |
| title | Impact of Spin in the Abstracts of Articles Reporting Results of Randomized Controlled Trials in the Field of Cancer: The SPIIN Randomized Controlled Trial. |
| title_full | Impact of Spin in the Abstracts of Articles Reporting Results of Randomized Controlled Trials in the Field of Cancer: The SPIIN Randomized Controlled Trial. |
| title_fullStr | Impact of Spin in the Abstracts of Articles Reporting Results of Randomized Controlled Trials in the Field of Cancer: The SPIIN Randomized Controlled Trial. |
| title_full_unstemmed | Impact of Spin in the Abstracts of Articles Reporting Results of Randomized Controlled Trials in the Field of Cancer: The SPIIN Randomized Controlled Trial. |
| title_short | Impact of Spin in the Abstracts of Articles Reporting Results of Randomized Controlled Trials in the Field of Cancer: The SPIIN Randomized Controlled Trial. |
| title_sort | impact of spin in the abstracts of articles reporting results of randomized controlled trials in the field of cancer the spiin randomized controlled trial |
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