CG base pair recognition within DNA triple helices using N-methyl-3H-pyrrolo[2,3-d]pyrimidin-2(7H)-one nucleoside analogues.
Triplex-mediated recognition of Py.Pu base pairs in DNA is a greater challenge than for Pu.Py base pairs as fewer hydrogen bonds are presented for binding in the major groove. Initial studies on m-aminophenyl-modified analogues of the bicyclic nucleoside N-methyl-3H-pyrrolo[2,3-d]pyrimidin-2(7 H)-on...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2007
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| _version_ | 1797074189677494272 |
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| author | Gerrard, SR Srinivasan, N Fox, K Brown, T |
| author_facet | Gerrard, SR Srinivasan, N Fox, K Brown, T |
| author_sort | Gerrard, SR |
| collection | OXFORD |
| description | Triplex-mediated recognition of Py.Pu base pairs in DNA is a greater challenge than for Pu.Py base pairs as fewer hydrogen bonds are presented for binding in the major groove. Initial studies on m-aminophenyl-modified analogues of the bicyclic nucleoside N-methyl-3H-pyrrolo[2,3-d]pyrimidin-2(7 H)-one suggest that selective recognition of the CG base pair is possible. |
| first_indexed | 2024-03-06T23:32:44Z |
| format | Journal article |
| id | oxford-uuid:6c9ee907-766d-46aa-ae74-300bcc8aa845 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:32:44Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:6c9ee907-766d-46aa-ae74-300bcc8aa8452022-03-26T19:12:06ZCG base pair recognition within DNA triple helices using N-methyl-3H-pyrrolo[2,3-d]pyrimidin-2(7H)-one nucleoside analogues.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:6c9ee907-766d-46aa-ae74-300bcc8aa845EnglishSymplectic Elements at Oxford2007Gerrard, SRSrinivasan, NFox, KBrown, TTriplex-mediated recognition of Py.Pu base pairs in DNA is a greater challenge than for Pu.Py base pairs as fewer hydrogen bonds are presented for binding in the major groove. Initial studies on m-aminophenyl-modified analogues of the bicyclic nucleoside N-methyl-3H-pyrrolo[2,3-d]pyrimidin-2(7 H)-one suggest that selective recognition of the CG base pair is possible. |
| spellingShingle | Gerrard, SR Srinivasan, N Fox, K Brown, T CG base pair recognition within DNA triple helices using N-methyl-3H-pyrrolo[2,3-d]pyrimidin-2(7H)-one nucleoside analogues. |
| title | CG base pair recognition within DNA triple helices using N-methyl-3H-pyrrolo[2,3-d]pyrimidin-2(7H)-one nucleoside analogues. |
| title_full | CG base pair recognition within DNA triple helices using N-methyl-3H-pyrrolo[2,3-d]pyrimidin-2(7H)-one nucleoside analogues. |
| title_fullStr | CG base pair recognition within DNA triple helices using N-methyl-3H-pyrrolo[2,3-d]pyrimidin-2(7H)-one nucleoside analogues. |
| title_full_unstemmed | CG base pair recognition within DNA triple helices using N-methyl-3H-pyrrolo[2,3-d]pyrimidin-2(7H)-one nucleoside analogues. |
| title_short | CG base pair recognition within DNA triple helices using N-methyl-3H-pyrrolo[2,3-d]pyrimidin-2(7H)-one nucleoside analogues. |
| title_sort | cg base pair recognition within dna triple helices using n methyl 3h pyrrolo 2 3 d pyrimidin 2 7h one nucleoside analogues |
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