Remodelling of microRNAs in colorectal cancer by hypoxia alters metabolism profiles and 5-fluorouracil resistance

Remodelling of microRNAs in colorectal cancer by hypoxia alters metabolism profiles and 5-fluorouracil resistance

Solid tumours have oxygen gradients and areas of near and almost total anoxia. Hypoxia reduces sensitivity to 5-fluorouracil (5-FU)-chemotherapy for colorectal cancer (CRC). MicroRNAs (miRNAs) are hypoxia sensors and were altered consistently in six CRC cell lines (colon cancer: DLD-1, HCT116 and HT...

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Detalles Bibliográficos
Main Authors: Nijhuis, A, Thompson, H, Adam, J, Parker, A, Gammon, L, Lewis, A, Bundy, J, Soga, T, Jalaly, A, Propper, D, Jeffery, R, Suraweera, N, McDonald, S, Thaha, M, Feakins, R, Lowe, R, Bishop, C, Silver, A
Formato: Journal article
Idioma:English
Publicado: Oxford University Press 2017

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