Remodelling of microRNAs in colorectal cancer by hypoxia alters metabolism profiles and 5-fluorouracil resistance
Solid tumours have oxygen gradients and areas of near and almost total anoxia. Hypoxia reduces sensitivity to 5-fluorouracil (5-FU)-chemotherapy for colorectal cancer (CRC). MicroRNAs (miRNAs) are hypoxia sensors and were altered consistently in six CRC cell lines (colon cancer: DLD-1, HCT116 and HT...
Հիմնական հեղինակներ: | Nijhuis, A, Thompson, H, Adam, J, Parker, A, Gammon, L, Lewis, A, Bundy, J, Soga, T, Jalaly, A, Propper, D, Jeffery, R, Suraweera, N, McDonald, S, Thaha, M, Feakins, R, Lowe, R, Bishop, C, Silver, A |
---|---|
Ձևաչափ: | Journal article |
Լեզու: | English |
Հրապարակվել է: |
Oxford University Press
2017
|
Նմանատիպ նյութեր
-
Analysis of colorectal cancers in British Bangladeshi identifies early onset, frequent mucinous histotype and a high prevalence of RBFOX1 deletion.
: Sengupta, N, և այլն
Հրապարակվել է: (2013) -
Genome analysis of colorectal cancers in British Bangladeshis identifies early onset and a high prevalence of rbfox1 deletion compared to Caucasians
: Sengupta, N, և այլն
Հրապարակվել է: (2013) -
The role of hypoxia regulated microRNAs in cancer.
: McCormick, R, և այլն
Հրապարակվել է: (2010) -
Hypoxia response and microRNAs: no longer two separate worlds.
: Ivan, M, և այլն
Հրապարակվել է: (2008) -
The Role of Hypoxia-Regulated MicroRNA in Cancer
: McCormick, R, և այլն
Հրապարակվել է: (2012)