Gene x gene interactions in genome wide association studies

Gene x gene interactions in genome wide association studies

<p>Genome wide association studies (GWAS) have revolutionized our approach to mapping genetic determinants of complex human diseases. However, even with success from recent studies, we have typically been able to explain only a fraction of the trait heritability. GWAS are typically analysed by...

Fuld beskrivelse

Bibliografiske detaljer
Hovedforfatter:	Bhattacharya, K
Andre forfattere:	Morris, A
Format:	Thesis
Sprog:	English
Udgivet:	2014
Fag:	Statistics (see also social sciences) Bioinformatics (technology) Bioinformatics (life sciences) Mathematical genetics and bioinformatics (statistics) Mathematical biology Genetics (life sciences) Mathematics

Lignende værker

Extensions of the case-control design in genome-wide association studies
af: Loizides, C
Udgivet: (2012)

Using phylogeny to improve genome-wide distant homology recognition
af: Abeln, S, et al.
Udgivet: (2007)

Quantifying the underestimation of relative risks from genome-wide association studies
af: Spencer, C, et al.
Udgivet: (2011)

Protein protein interactions, evolutionary rate, abundance and age
af: Saeed, R, et al.
Udgivet: (2006)

Cotranslational protein folding - fact or fiction?
af: Deane, C, et al.
Udgivet: (2007)

Modelling sequential protein folding under kinetic control
af: Huard, F, et al.
Udgivet: (2006)

A statistical approach using network structure in the prediction of protein characteristics
af: Chen, P, et al.
Udgivet: (2007)

Multilocus approaches to the detection of disease susceptibility regions: methods and applications
af: Ciampa, J
Udgivet: (2012)

Statistical HLA type imputation from large and heterogeneous datasets
af: Dilthey, A
Udgivet: (2012)

Rahnuma: hypergraph-based tool for metabolic pathway prediction and network comparison
af: Mithani, A, et al.
Udgivet: (2009)

Increasing statistical power and generalizability in genomics microarray research
af: Ramasamy, A
Udgivet: (2009)

HLA*IMP - an integrated framework for imputing classical HLA alleles from SNP genotypes
af: Dilthey, A, et al.
Udgivet: (2011)

Bayesian methods for multivariate phenotype analysis in genome-wide association studies
af: Iotchkova, V
Udgivet: (2013)

Design and analysis of genome-wide association studies
af: Barrett, J
Udgivet: (2008)

An integrated genomic approach for the identification and analysis of single nucleotide polymorphisms that affect cancer in humans
af: Repapi, E
Udgivet: (2013)

Bayesian methods for estimating human ancestry using whole genome SNP data
af: Churchhouse, C
Udgivet: (2012)

The estimation of recombination rates from population genetic data
af: Auton, A
Udgivet: (2007)

Statistical challenges in the detection of mutation and variation using high throughput sequencing
af: Pfeifer, S
Udgivet: (2012)

Statistical and Computational Methodology for the Analysis of Forensic DNA Mixtures with Artefacts
af: Graversen, T
Udgivet: (2014)

Exploring the fold space preferences of ancient and newborn protein superfamilies
af: Edwards, H, et al.
Udgivet: (2014)

Application of the Neutral Indel Model to genome sequences for diverse metazoans
af: Meader, S
Udgivet: (2010)

Protein loop structure prediction
af: Choi, Y
Udgivet: (2011)

Large-scale genetic analysis of quantitative traits
af: Randall, J, et al.
Udgivet: (2012)

A method for the identification of biological pathways
af: Honti, F
Udgivet: (2014)

On genetic variants underlying common disease
af: Hechter, E
Udgivet: (2011)

Bayesian and frequentist methods and analyses of genome-wide association studies
af: Vukcevic, D
Udgivet: (2009)

Selection along the HIV-1 genome through the CTL mediated immune response
af: Palmer, D
Udgivet: (2014)

Imputation aided analysis of the association between autoimmune diseases and the MHC
af: Moutsianas, L
Udgivet: (2011)

Inferring the fine-scale structure and evolution of recombination from high-throughput genome sequencing
af: Venn, O
Udgivet: (2013)

The evolutionary dynamics of neutral networks: lessons from RNA
af: Rendel, M
Udgivet: (2008)

Genome-wide DNaseI hypersensitive sites profiles in laboratory mouse strains by DNase-seq
af: Hosseini, M
Udgivet: (2013)

Protein fold evolution on completed genomes: distinguishing between young and old folds
af: Abeln, S, et al.
Udgivet: (2007)

Genome annotation and selectional analysis of viral evolution
af: de Groot, S
Udgivet: (2008)

Fold recognition and alignment in the ‘twilight zone’
af: Hill, J, et al.
Udgivet: (2013)

Statistical methods for the analysis of genetic association studies
af: Su, Z
Udgivet: (2008)

Bayesian methods for fine mapping in genetic association studies
af: Frangou, E
Udgivet: (2013)

Genes contributing to variation in fear-related behaviour
af: Krohn, J, et al.
Udgivet: (2013)

A robust clustering algorithm for identifying problematic samples in genome-wide association studies
af: Bellenguez, C, et al.
Udgivet: (2012)

Statistical models for single-cell data
af: Pierson, E
Udgivet: (2015)

A flexible and accurate genotype imputation method for the next generation of genome-wide association studies
af: Howie, B, et al.
Udgivet: (2009)