Two loci on chromosomes 2 and X for premature coronary heart disease identified in early- and late-settlement populations of Finland.
Coronary heart disease (CHD) is a complex disorder constituting a major health problem in Western societies. To assess the genetic background of CHD, we performed a genomewide linkage scan in two study samples from the genetically isolated population of Finland. An initial study sample consisted of...
| Main Authors: | , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2000
|
| _version_ | 1797074246860537856 |
|---|---|
| author | Pajukanta, P Cargill, M Viitanen, L Nuotio, I Kareinen, A Perola, M Terwilliger, J Kempas, E Daly, M Lilja, H Rioux, J Brettin, T Viikari, J Rönnemaa, T Laakso, M Lander, E Peltonen, L |
| author_facet | Pajukanta, P Cargill, M Viitanen, L Nuotio, I Kareinen, A Perola, M Terwilliger, J Kempas, E Daly, M Lilja, H Rioux, J Brettin, T Viikari, J Rönnemaa, T Laakso, M Lander, E Peltonen, L |
| author_sort | Pajukanta, P |
| collection | OXFORD |
| description | Coronary heart disease (CHD) is a complex disorder constituting a major health problem in Western societies. To assess the genetic background of CHD, we performed a genomewide linkage scan in two study samples from the genetically isolated population of Finland. An initial study sample consisted of family material from the northeastern part of Finland, settled by a small number of founders approximately 300 years ago. A second study sample originated from the southwestern region of Finland, settled approximately 2,000 years ago. Families were ascertained through probands exhibiting premature CHD, defined as >50% stenosis of at least two coronary arteries at a young age, as verified by coronary angiography. Both study samples and the pooled data set provided evidence for linkage in two chromosomal regions. A region on chromosome 2q21.1-22 yielded two-point LOD scores of 3.2, 1.9, and 3.7, in the affected sib-pair (ASP) analyses of the northeastern, southwestern, and pooled study samples. The corresponding multipoint maximum-likelihood scores (MLSs) for these three study samples were 2.4, 1.3, and 3.0. In addition, a region on chromosome Xq23-26 resulted in two-point LOD scores of 1.9, 3.5, and 2.9 and in multipoint MLSs of 3.4, 3.1, and 2.5, respectively. In conclusion, this study identifies two loci likely to contribute to premature CHD: one on chromosome 2q21.1-22 and another on chromosome Xq23-26. |
| first_indexed | 2024-03-06T23:33:22Z |
| format | Journal article |
| id | oxford-uuid:6cce7e56-84ae-4353-90e4-79466eec0ca1 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:33:22Z |
| publishDate | 2000 |
| record_format | dspace |
| spelling | oxford-uuid:6cce7e56-84ae-4353-90e4-79466eec0ca12022-03-26T19:13:36ZTwo loci on chromosomes 2 and X for premature coronary heart disease identified in early- and late-settlement populations of Finland.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:6cce7e56-84ae-4353-90e4-79466eec0ca1EnglishSymplectic Elements at Oxford2000Pajukanta, PCargill, MViitanen, LNuotio, IKareinen, APerola, MTerwilliger, JKempas, EDaly, MLilja, HRioux, JBrettin, TViikari, JRönnemaa, TLaakso, MLander, EPeltonen, LCoronary heart disease (CHD) is a complex disorder constituting a major health problem in Western societies. To assess the genetic background of CHD, we performed a genomewide linkage scan in two study samples from the genetically isolated population of Finland. An initial study sample consisted of family material from the northeastern part of Finland, settled by a small number of founders approximately 300 years ago. A second study sample originated from the southwestern region of Finland, settled approximately 2,000 years ago. Families were ascertained through probands exhibiting premature CHD, defined as >50% stenosis of at least two coronary arteries at a young age, as verified by coronary angiography. Both study samples and the pooled data set provided evidence for linkage in two chromosomal regions. A region on chromosome 2q21.1-22 yielded two-point LOD scores of 3.2, 1.9, and 3.7, in the affected sib-pair (ASP) analyses of the northeastern, southwestern, and pooled study samples. The corresponding multipoint maximum-likelihood scores (MLSs) for these three study samples were 2.4, 1.3, and 3.0. In addition, a region on chromosome Xq23-26 resulted in two-point LOD scores of 1.9, 3.5, and 2.9 and in multipoint MLSs of 3.4, 3.1, and 2.5, respectively. In conclusion, this study identifies two loci likely to contribute to premature CHD: one on chromosome 2q21.1-22 and another on chromosome Xq23-26. |
| spellingShingle | Pajukanta, P Cargill, M Viitanen, L Nuotio, I Kareinen, A Perola, M Terwilliger, J Kempas, E Daly, M Lilja, H Rioux, J Brettin, T Viikari, J Rönnemaa, T Laakso, M Lander, E Peltonen, L Two loci on chromosomes 2 and X for premature coronary heart disease identified in early- and late-settlement populations of Finland. |
| title | Two loci on chromosomes 2 and X for premature coronary heart disease identified in early- and late-settlement populations of Finland. |
| title_full | Two loci on chromosomes 2 and X for premature coronary heart disease identified in early- and late-settlement populations of Finland. |
| title_fullStr | Two loci on chromosomes 2 and X for premature coronary heart disease identified in early- and late-settlement populations of Finland. |
| title_full_unstemmed | Two loci on chromosomes 2 and X for premature coronary heart disease identified in early- and late-settlement populations of Finland. |
| title_short | Two loci on chromosomes 2 and X for premature coronary heart disease identified in early- and late-settlement populations of Finland. |
| title_sort | two loci on chromosomes 2 and x for premature coronary heart disease identified in early and late settlement populations of finland |
| work_keys_str_mv | AT pajukantap twolocionchromosomes2andxforprematurecoronaryheartdiseaseidentifiedinearlyandlatesettlementpopulationsoffinland AT cargillm twolocionchromosomes2andxforprematurecoronaryheartdiseaseidentifiedinearlyandlatesettlementpopulationsoffinland AT viitanenl twolocionchromosomes2andxforprematurecoronaryheartdiseaseidentifiedinearlyandlatesettlementpopulationsoffinland AT nuotioi twolocionchromosomes2andxforprematurecoronaryheartdiseaseidentifiedinearlyandlatesettlementpopulationsoffinland AT kareinena twolocionchromosomes2andxforprematurecoronaryheartdiseaseidentifiedinearlyandlatesettlementpopulationsoffinland AT perolam twolocionchromosomes2andxforprematurecoronaryheartdiseaseidentifiedinearlyandlatesettlementpopulationsoffinland AT terwilligerj twolocionchromosomes2andxforprematurecoronaryheartdiseaseidentifiedinearlyandlatesettlementpopulationsoffinland AT kempase twolocionchromosomes2andxforprematurecoronaryheartdiseaseidentifiedinearlyandlatesettlementpopulationsoffinland AT dalym twolocionchromosomes2andxforprematurecoronaryheartdiseaseidentifiedinearlyandlatesettlementpopulationsoffinland AT liljah twolocionchromosomes2andxforprematurecoronaryheartdiseaseidentifiedinearlyandlatesettlementpopulationsoffinland AT riouxj twolocionchromosomes2andxforprematurecoronaryheartdiseaseidentifiedinearlyandlatesettlementpopulationsoffinland AT brettint twolocionchromosomes2andxforprematurecoronaryheartdiseaseidentifiedinearlyandlatesettlementpopulationsoffinland AT viikarij twolocionchromosomes2andxforprematurecoronaryheartdiseaseidentifiedinearlyandlatesettlementpopulationsoffinland AT ronnemaat twolocionchromosomes2andxforprematurecoronaryheartdiseaseidentifiedinearlyandlatesettlementpopulationsoffinland AT laaksom twolocionchromosomes2andxforprematurecoronaryheartdiseaseidentifiedinearlyandlatesettlementpopulationsoffinland AT landere twolocionchromosomes2andxforprematurecoronaryheartdiseaseidentifiedinearlyandlatesettlementpopulationsoffinland AT peltonenl twolocionchromosomes2andxforprematurecoronaryheartdiseaseidentifiedinearlyandlatesettlementpopulationsoffinland |