Crystal structure of the PHF8 Jumonji domain, an Nepsilon-methyl lysine demethylase.

Crystal structure of the PHF8 Jumonji domain, an Nepsilon-methyl lysine demethylase.

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Crystallographic analysis of the catalytic domain of PHD finger protein 8 (PHF8), an N(epsilon)-methyl lysine histone demethylase associated with mental retardation and cleft lip/palate, reveals a double-stranded beta-helix fold with conserved Fe(II) and cosubstrate binding sites typical of the 2-ox...

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Bibliographic Details
Main Authors:	Yue, W, Hozjan, V, Ge, W, Loenarz, C, Cooper, C, Schofield, C, Kavanagh, K, Oppermann, U, McDonough, M
Format:	Journal article
Language:	English
Published:	2010

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