Notum deacylates octanoylated ghrelin
<strong>Objectives</strong> The only proteins known to be modified by O-linked lipidation are Wnts and ghrelin, and enzymatic removal of this post-translational modification inhibits ligand activity. Indeed, the Wnt-deacylase activity of Notum is the basis of its ability to act as a feed...
Main Authors: | Zhao, Y, Schuhmacher, L-N, Roberts, M, Jones, EY, Et al. |
---|---|
Format: | Journal article |
Language: | English |
Published: |
Elsevier
2021
|
Similar Items
-
Ghrelin octanoylation by ghrelin O-acyltransferase: protein acylation impacting metabolic and neuroendocrine signalling
by: Tasha R. Davis, et al.
Published: (2021-07-01) -
Structural characterization of melatonin as an inhibitor of the Wnt deacylase Notum
by: Zhao, Y, et al.
Published: (2020) -
Caffeine inhibits Notum activity by binding at the catalytic pocket
by: Zhao, Y, et al.
Published: (2020) -
Scaffold-hopping identifies furano[2,3-d]pyrimidine amides as potent Notum inhibitors
by: Atkinson, BN, et al.
Published: (2019) -
Computational Analysis of the Inhibition Mechanism of NOTUM by the ONIOM Method
by: Ibrahim Yildiz, et al.
Published: (2022-04-01)