Cross-sectional associations between Ideal Cardiovascular Health scores and vascular phenotypes in 11- to 12-year-olds and their parents: the Longitudinal Study of Australian Children

<p>Background: Understanding early-life relationships between the Ideal Cardiovascular Health (ICVH) score and vascular phenotypes could inform likely effectiveness and timing of cardiovascular disease prevention strategies. We aimed to describe associations between ICVH scores and vascular ph...

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Hlavní autoři: Liu, R, Wake, M, Grobler, A, Cheung, M, Lycett, K, Ranganathan, S, Edwards, B, Dwyer, T, Azzopardi, P, Juonala, M, Burgner, D
Médium: Journal article
Jazyk:English
Vydáno: Elsevier 2018
_version_ 1826277765906694144
author Liu, R
Wake, M
Grobler, A
Cheung, M
Lycett, K
Ranganathan, S
Edwards, B
Dwyer, T
Azzopardi, P
Juonala, M
Burgner, D
author_facet Liu, R
Wake, M
Grobler, A
Cheung, M
Lycett, K
Ranganathan, S
Edwards, B
Dwyer, T
Azzopardi, P
Juonala, M
Burgner, D
author_sort Liu, R
collection OXFORD
description <p>Background: Understanding early-life relationships between the Ideal Cardiovascular Health (ICVH) score and vascular phenotypes could inform likely effectiveness and timing of cardiovascular disease prevention strategies. We aimed to describe associations between ICVH scores and vascular phenotypes in 11- to 12-year-old children and their parents.</p><p> Methods and results: Cross-sectional ICVH scores (range 0–7, higher indicating better health), derived by summing dichotomized metrics for cholesterol, glucose, blood pressure (BP), body mass index (BMI), diet, physical activity and smoking, were constructed for 1235 adults (89% female, mean age 43 years) and 1028 children (48% female, 12 years). The median scores were 4 and 5 for adults and children respectively. Child ICVH scores were associated with parent scores (0.18 higher child score per additional point in parent's score, 95% CI 0.12 to 0.22, P &lt; 0.001). Each additional point in the adult ICVH score was associated with slower carotid-femoral pulse wave velocity (PWV, −0.32 m/s, 95% CI −0.37 to −0.27), greater carotid elasticity (0.017%/mm Hg, 95% CI 0.014 to 0.020) and reduced carotid intima-media thickness (IMT, −7.3 μm, 95% CI −12.0 to −2.5). An additional point in the child score was associated with functional phenotypes (PWV −0.07 m/s, 95% CI −0.11 to −0.03; carotid elasticity 0.009%/mm Hg, 95% CI 0.004 to 0.015) but not structural phenotypes (IMT −1.8 μm, 95% CI −5.2 to 1.5).</p><p> Conclusion: Few Australian children and even fewer parents have ideal cardiovascular health. Lower ICVH scores were associated with adverse adult vascular phenotypes and adverse child vascular function. Family-based interventions optimizing ICVH metrics may delay onset and progression of subclinical atherosclerosis and later cardiovascular disease.</p>
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spelling oxford-uuid:6cf5f1d2-c1fa-4be1-abf0-c8f268ee25a22022-03-26T19:14:38ZCross-sectional associations between Ideal Cardiovascular Health scores and vascular phenotypes in 11- to 12-year-olds and their parents: the Longitudinal Study of Australian ChildrenJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:6cf5f1d2-c1fa-4be1-abf0-c8f268ee25a2EnglishSymplectic Elements at OxfordElsevier2018Liu, RWake, MGrobler, ACheung, MLycett, KRanganathan, SEdwards, BDwyer, TAzzopardi, PJuonala, MBurgner, D<p>Background: Understanding early-life relationships between the Ideal Cardiovascular Health (ICVH) score and vascular phenotypes could inform likely effectiveness and timing of cardiovascular disease prevention strategies. We aimed to describe associations between ICVH scores and vascular phenotypes in 11- to 12-year-old children and their parents.</p><p> Methods and results: Cross-sectional ICVH scores (range 0–7, higher indicating better health), derived by summing dichotomized metrics for cholesterol, glucose, blood pressure (BP), body mass index (BMI), diet, physical activity and smoking, were constructed for 1235 adults (89% female, mean age 43 years) and 1028 children (48% female, 12 years). The median scores were 4 and 5 for adults and children respectively. Child ICVH scores were associated with parent scores (0.18 higher child score per additional point in parent's score, 95% CI 0.12 to 0.22, P &lt; 0.001). Each additional point in the adult ICVH score was associated with slower carotid-femoral pulse wave velocity (PWV, −0.32 m/s, 95% CI −0.37 to −0.27), greater carotid elasticity (0.017%/mm Hg, 95% CI 0.014 to 0.020) and reduced carotid intima-media thickness (IMT, −7.3 μm, 95% CI −12.0 to −2.5). An additional point in the child score was associated with functional phenotypes (PWV −0.07 m/s, 95% CI −0.11 to −0.03; carotid elasticity 0.009%/mm Hg, 95% CI 0.004 to 0.015) but not structural phenotypes (IMT −1.8 μm, 95% CI −5.2 to 1.5).</p><p> Conclusion: Few Australian children and even fewer parents have ideal cardiovascular health. Lower ICVH scores were associated with adverse adult vascular phenotypes and adverse child vascular function. Family-based interventions optimizing ICVH metrics may delay onset and progression of subclinical atherosclerosis and later cardiovascular disease.</p>
spellingShingle Liu, R
Wake, M
Grobler, A
Cheung, M
Lycett, K
Ranganathan, S
Edwards, B
Dwyer, T
Azzopardi, P
Juonala, M
Burgner, D
Cross-sectional associations between Ideal Cardiovascular Health scores and vascular phenotypes in 11- to 12-year-olds and their parents: the Longitudinal Study of Australian Children
title Cross-sectional associations between Ideal Cardiovascular Health scores and vascular phenotypes in 11- to 12-year-olds and their parents: the Longitudinal Study of Australian Children
title_full Cross-sectional associations between Ideal Cardiovascular Health scores and vascular phenotypes in 11- to 12-year-olds and their parents: the Longitudinal Study of Australian Children
title_fullStr Cross-sectional associations between Ideal Cardiovascular Health scores and vascular phenotypes in 11- to 12-year-olds and their parents: the Longitudinal Study of Australian Children
title_full_unstemmed Cross-sectional associations between Ideal Cardiovascular Health scores and vascular phenotypes in 11- to 12-year-olds and their parents: the Longitudinal Study of Australian Children
title_short Cross-sectional associations between Ideal Cardiovascular Health scores and vascular phenotypes in 11- to 12-year-olds and their parents: the Longitudinal Study of Australian Children
title_sort cross sectional associations between ideal cardiovascular health scores and vascular phenotypes in 11 to 12 year olds and their parents the longitudinal study of australian children
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