Infection with hepatitis B and C viruses and risk of lymphoid malignancies in the European Prospective Investigation into Cancer and Nutrition (EPIC).
BACKGROUND: Case-control studies suggested a moderate, but consistent, association of hepatitis C virus (HCV) infection with lymphoid tissue malignancies, especially non-Hodgkin lymphoma (NHL). More limited data suggested that hepatitis B virus (HBV) infection might also be associated with NHL. Howe...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2011
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| _version_ | 1797074294702866432 |
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| author | Franceschi, S Lise, M Trépo, C Berthillon, P Chuang, S Nieters, A Travis, R Vermeulen, R Overvad, K Tjønneland, A Olsen, A Bergmann, M Boeing, H Kaaks, R Becker, N Trichopoulou, A Lagiou, P Bamia, C Palli, D Sieri, S Panico, S Tumino, R Sacerdote, C Bueno-de-Mesquita, B Peeters, P |
| author_facet | Franceschi, S Lise, M Trépo, C Berthillon, P Chuang, S Nieters, A Travis, R Vermeulen, R Overvad, K Tjønneland, A Olsen, A Bergmann, M Boeing, H Kaaks, R Becker, N Trichopoulou, A Lagiou, P Bamia, C Palli, D Sieri, S Panico, S Tumino, R Sacerdote, C Bueno-de-Mesquita, B Peeters, P |
| author_sort | Franceschi, S |
| collection | OXFORD |
| description | BACKGROUND: Case-control studies suggested a moderate, but consistent, association of hepatitis C virus (HCV) infection with lymphoid tissue malignancies, especially non-Hodgkin lymphoma (NHL). More limited data suggested that hepatitis B virus (HBV) infection might also be associated with NHL. However, prospective studies on the topic are few. METHODS: A nested case-control study was conducted in eight countries participating in the EPIC prospective study. Seven hundred thirty-nine incident cases of NHL, 238 multiple myeloma (MM), and 46 Hodgkin lymphoma (HL) were matched with 2,028 controls. Seropositivity to anti-HCV, anti-HBc, and HBsAg was evaluated and conditional logistic regression was used to estimate odds ratios (OR) and corresponding 95% confidence intervals (CI) for NHL, MM, or HL, and their combination. RESULTS: Anti-HCV seropositivity among controls in different countries ranged from 0% to 5.3%; HBsAg from 0% to 2.7%; and anti-HBc from 1.9% to 45.9%. Similar nonsignificant associations were found with seropositivity to HBsAg for NHL (OR = 1.78; 95% CI: 0.78-4.04), MM (OR = 4.00; 95% CI: 1.00-16.0), and HL (OR = 2.00; 95% CI: 0.13-32.0). The association between HBsAg and the combination of NHL, MM, and HL (OR = 2.21; 95% CI: 1.12-4.33) was similar for cancer diagnosed less than 3 and 3 or more years after blood collection. No significant association was found between anti-HCV and NHL, MM, or HL risk, but the corresponding CIs were very broad. CONCLUSIONS: Chronic HBV infection may increase the risk of lymphoid malignancies among healthy European volunteers. IMPACT: Treatment directed at control of HBV infection should be evaluated in HBsAg-seropositive patients with lymphoid tissue malignancies. |
| first_indexed | 2024-03-06T23:34:05Z |
| format | Journal article |
| id | oxford-uuid:6d0e12d9-f1d9-4be5-9f61-8376e9b49208 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:34:05Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oxford-uuid:6d0e12d9-f1d9-4be5-9f61-8376e9b492082022-03-26T19:15:14ZInfection with hepatitis B and C viruses and risk of lymphoid malignancies in the European Prospective Investigation into Cancer and Nutrition (EPIC).Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:6d0e12d9-f1d9-4be5-9f61-8376e9b49208EnglishSymplectic Elements at Oxford2011Franceschi, SLise, MTrépo, CBerthillon, PChuang, SNieters, ATravis, RVermeulen, ROvervad, KTjønneland, AOlsen, ABergmann, MBoeing, HKaaks, RBecker, NTrichopoulou, ALagiou, PBamia, CPalli, DSieri, SPanico, STumino, RSacerdote, CBueno-de-Mesquita, BPeeters, PBACKGROUND: Case-control studies suggested a moderate, but consistent, association of hepatitis C virus (HCV) infection with lymphoid tissue malignancies, especially non-Hodgkin lymphoma (NHL). More limited data suggested that hepatitis B virus (HBV) infection might also be associated with NHL. However, prospective studies on the topic are few. METHODS: A nested case-control study was conducted in eight countries participating in the EPIC prospective study. Seven hundred thirty-nine incident cases of NHL, 238 multiple myeloma (MM), and 46 Hodgkin lymphoma (HL) were matched with 2,028 controls. Seropositivity to anti-HCV, anti-HBc, and HBsAg was evaluated and conditional logistic regression was used to estimate odds ratios (OR) and corresponding 95% confidence intervals (CI) for NHL, MM, or HL, and their combination. RESULTS: Anti-HCV seropositivity among controls in different countries ranged from 0% to 5.3%; HBsAg from 0% to 2.7%; and anti-HBc from 1.9% to 45.9%. Similar nonsignificant associations were found with seropositivity to HBsAg for NHL (OR = 1.78; 95% CI: 0.78-4.04), MM (OR = 4.00; 95% CI: 1.00-16.0), and HL (OR = 2.00; 95% CI: 0.13-32.0). The association between HBsAg and the combination of NHL, MM, and HL (OR = 2.21; 95% CI: 1.12-4.33) was similar for cancer diagnosed less than 3 and 3 or more years after blood collection. No significant association was found between anti-HCV and NHL, MM, or HL risk, but the corresponding CIs were very broad. CONCLUSIONS: Chronic HBV infection may increase the risk of lymphoid malignancies among healthy European volunteers. IMPACT: Treatment directed at control of HBV infection should be evaluated in HBsAg-seropositive patients with lymphoid tissue malignancies. |
| spellingShingle | Franceschi, S Lise, M Trépo, C Berthillon, P Chuang, S Nieters, A Travis, R Vermeulen, R Overvad, K Tjønneland, A Olsen, A Bergmann, M Boeing, H Kaaks, R Becker, N Trichopoulou, A Lagiou, P Bamia, C Palli, D Sieri, S Panico, S Tumino, R Sacerdote, C Bueno-de-Mesquita, B Peeters, P Infection with hepatitis B and C viruses and risk of lymphoid malignancies in the European Prospective Investigation into Cancer and Nutrition (EPIC). |
| title | Infection with hepatitis B and C viruses and risk of lymphoid malignancies in the European Prospective Investigation into Cancer and Nutrition (EPIC). |
| title_full | Infection with hepatitis B and C viruses and risk of lymphoid malignancies in the European Prospective Investigation into Cancer and Nutrition (EPIC). |
| title_fullStr | Infection with hepatitis B and C viruses and risk of lymphoid malignancies in the European Prospective Investigation into Cancer and Nutrition (EPIC). |
| title_full_unstemmed | Infection with hepatitis B and C viruses and risk of lymphoid malignancies in the European Prospective Investigation into Cancer and Nutrition (EPIC). |
| title_short | Infection with hepatitis B and C viruses and risk of lymphoid malignancies in the European Prospective Investigation into Cancer and Nutrition (EPIC). |
| title_sort | infection with hepatitis b and c viruses and risk of lymphoid malignancies in the european prospective investigation into cancer and nutrition epic |
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