Genetic pathways in colorectal cancer.

Genetic pathways in colorectal cancer.

The model of colorectal tumorigenesis put forward by Fearon and Vogelstein has had great influence on molecular oncology. They proposed that a series of mutations occur in the progression from normal cells to colorectal cancer and that these mutations are associated with the histological features of...

Bibliográfalaš dieđut
Váldodahkkit:	Ilyas, M, Tomlinson, I
Materiálatiipa:	Journal article
Giella:	English
Almmustuhtton:	1996

Geahča maid

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Beta-catenin mutations in cell lines established from human colorectal cancers.
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Genetic pathways of colorectal carcinogenesis rarely involve the PTEN and LKB1 genes outside the inherited hamartoma syndromes.
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Mutations within Wnt pathway genes in sporadic colorectal cancers and cell lines.
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The low frequency of beta-catenin mutations in cell lines established from human colorectal cancers
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Loss of Bcl-2 expression correlates with tumour recurrence in colorectal cancer.
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Much of the genetic risk of colorectal cancer is likely to be mediated through susceptibility to adenomas.
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Tumour recurrence is associated with Jass grouping but not with differences in E-cadherin expression in moderately differentiated Dukes' B colorectal cancers.
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Deciphering the genetic architecture of low-penetrance susceptibility to colorectal cancer.
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Sex hormones and genetic variants in hormone metabolic pathways associated with the risk of colorectal cancer
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Effects of genetic variations in the Adiponectin pathway genes on the risk of colorectal cancer in the Chinese population
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Hereditary colorectal cancer: genetics and screening diagnostics
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Optimising methods for determining RER status in colorectal cancers.
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Evidence against a major genetic basis for combined breast and colorectal cancer susceptibility.
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Defining the clinical phenotype of hereditary nonpolyposis colorectal cancer
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Towards a multiscale model of colorectal cancer.
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Genetic testing is important in families with a history suggestive of hereditary non-polyposis colorectal cancer even if the Amsterdam criteria are not fulfilled.
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